Spontaneous oscillation of oxy- and deoxy- hemoglobin changes with a phase difference throughout the occipital cortex of newborn infants observed using non-invasive optical topography

Taga, Gentaro; Konishi, Y.; Maki, Atsushi; Tachibana, Tatsushi; Fujiwara, Michiyuki; Koizumi, Hideaki

doi:10.1016/s0304-3940(00)00874-0

Cited by 128 publications

(76 citation statements)

References 19 publications

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“…In a previous study, the cerebral blood velocity in infants measured by Doppler ultrasound showed cyclical fluctuations with frequency ranging from 1.5 to 5 cycles/min (19). NIRS studies have also shown oscillations of the Hb oxygenation state with frequency ranging from 3 to 5 cycles/min (20). Therefore, the use of average values for a period of 5 min in each neonate in this study seems sufficient for estimation of cerebral Hb in a steady state.…”

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confidence: 46%

Developmental Changes of Optical Properties in Neonates Determined by Near-Infrared Time-Resolved Spectroscopy

et al. 2005

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Near-infrared spectroscopy has been used for measurement of changes in cerebral Hb concentrations in infants to study cerebral oxygenation and hemodynamics. In this study, measurements by time-resolved spectroscopy (TRS) were performed in 22 neonates to estimate the values of light absorption coefficient and reduced scattering coefficient (' s ), cerebral Hb oxygen saturation (ScO 2 ), cerebral blood volume (CBV), and differential pathlength factor (DPF), and the relationships between postconceptional age and ' s , ScO 2 , CBV, and DPF were investigated. A portable three-wavelength TRS system with a probe attached to the head of the neonate was used. The mean ' s values at 761, 795, and 835 nm in neonates were estimated to be (mean Ϯ SD) 6.46 Ϯ 1.21, 5.90 Ϯ 1.15 and 6.40 Ϯ 1.16/cm, respectively. There was a significant positive relationship between postconceptional age and ' s at those three wavelengths. The mean ScO 2 value was calculated to be 70.0 Ϯ 4.6%, and postconceptional age and ScO 2 showed a negative linear relationship. The mean value of CBV was 2.31 Ϯ 0.56 mL/100 g. There was a significant positive relationship between postconceptional age and CBV. During the perinatal period, the brain undergoes anatomic, functional, and metabolic changes. The anatomic changes include neuronal proliferation, migration, organization, and myelination, and the metabolic changes match the process of initial overproduction and subsequent elimination of excessive neurons, synapses, and dendritic spines known to occur in the developing brain. Noninvasive assessment of cerebral anatomic changes and of oxygen delivery and utilization is useful for evaluating the effectiveness of therapy and for preventing oxygen toxicity in seriously ill neonates.Near-infrared spectroscopy (NIRS) has been used in the clinical field with various measuring devices using several wavelengths. A method using continuous-wave NIRS has been developed and reported to be suitable for clinical use in infants (1-7). However, current commercially available NIRS systems can detect only changes in cerebral Hb. Because NIRS is based on the modified Beer-Lambert law, a change in hematocrit and blood volume as well as developmental and pathophysiologic changes in brain tissue affect the pathlength of near-infrared light. In a few recent studies, absolute values of cerebral Hb oxygen saturation (ScO 2 ) and cerebral blood volume (CBV) in infants were measured without inducing Hb concentration changes by using full-spectral near-infrared spectroscopy (8 -11) and spatially resolved spectroscopy (12). However, these

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confidence: 46%

Developmental Changes of Optical Properties in Neonates Determined by Near-Infrared Time-Resolved Spectroscopy

et al. 2005

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“…We previously revealed the patterns of spontaneous oscillation in the infant brain by using multichannel NIRS (Taga et al, 2000). NIRS has also been successfully used to investigate cortical activation in infants (Peña et was emitted from laser diodes through incident optical fibers (maximum intensity: 0.4 mW for neonates, 0.6 mW for 3-month-old infants, and 1.2 mW for 6-month-old infants).…”

Section: Methodsmentioning

confidence: 99%

“…Spontaneous fluctuations have been reported in the cerebral blood oxygenation in sleeping infants (Taga et al, 2000). Spontaneous fluctuations were measured during the task-free (resting) state; this method is especially useful for investigating neural systems at multiple stages of development.…”

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confidence: 99%

Development of Global Cortical Networks in Early Infancy

Homae¹,

Watanabe²,

Otobe³

et al. 2010

J. Neurosci.

188

219

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Human cognition and behaviors are subserved by global networks of neural mechanisms. Although the organization of the brain is a subject of interest, the process of development of global cortical networks in early infancy has not yet been clarified. In the present study, we explored developmental changes in these networks from several days to 6 months after birth by examining spontaneous fluctuations in brain activity, using multichannel near-infrared spectroscopy. We set up 94 measurement channels over the frontal, temporal, parietal, and occipital regions of the infant brain. The obtained signals showed complex time-series properties, which were characterized as 1/f fluctuations. To reveal the functional connectivity of the cortical networks, we calculated the temporal correlations of continuous signals between all the pairs of measurement channels. We found that the cortical network organization showed regional dependency and dynamic changes in the course of development. In the temporal, parietal, and occipital regions, connectivity increased between homologous regions in the two hemispheres and within hemispheres; in the frontal regions, it decreased progressively. Frontoposterior connectivity changed to a "U-shaped" pattern within 6 months: it decreases from the neonatal period to the age of 3 months and increases from the age of 3 months to the age of 6 months. We applied cluster analyses to the correlation coefficients and showed that the bilateral organization of the networks begins to emerge during the first 3 months of life. Our findings suggest that these developing networks, which form multiple clusters, are precursors of the functional cerebral architecture.

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“…Although both oxy-and deoxy-Hb signal changes represent hemodynamic responses to neural activity, the relative phase between the oxy-and deoxy-Hb signals reflects complex interplay among neurovascular and metabolic processes (16,26,27). Studies of the spontaneous fluctuations of oxy-and deoxy-Hb in the cortex of sleeping infants have shown the presence of stable phase differences between oxy-and deoxy-Hb signals (25,28). However, limited information is available regarding age-dependent changes in Hb phase differences in typically and atypically developing brains.…”

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confidence: 99%

Hemoglobin phase of oxygenation and deoxygenation in early brain development measured using fNIRS

Watanabe

Shitara

Aoki

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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A crucial issue in neonatal medicine is the impact of preterm birth on the developmental trajectory of the brain. Although a growing number of studies have shown alterations in the structure and function of the brain in preterm-born infants, we propose a method to detect subtle differences in neurovascular and metabolic functions in neonates and infants. Functional near-infrared spectroscopy (fNIRS) was used to obtain time-averaged phase differences between spontaneous low-frequency (less than 0.1 Hz) oscillatory changes in oxygenated hemoglobin (oxy-Hb) and those in deoxygenated hemoglobin (deoxy-Hb). This phase difference was referred to as hemoglobin phase of oxygenation and deoxygenation (hPod) in the cerebral tissue of sleeping neonates and infants. We examined hPod in term, late preterm, and early preterm infants with no evidence of clinical issues and found that all groups of infants showed developmental changes in the values of hPod from an inphase to an antiphase pattern. Comparison of hPod among the groups revealed that developmental changes in hPod in early preterm infants precede those in late preterm and term infants at term equivalent age but then, progress at a slower pace. This study suggests that hPod measured using fNIRS is sensitive to the developmental stage of the integration of circular, neurovascular, and metabolic functions in the brains of neonates and infants.irth is a drastic event for the developing brain, because this is when the oxygen supply switches from the fetal-placental circulation to an autonomous system. In addition, the extrauterine environment begins to provide the neonate with a tremendous flow of stimuli. Earlier exposure to the extrauterine environment is thought to influence the developmental trajectory of the brain. It has long been known that preterm birth affects brain development and is associated with a higher rate of neurodevelopmental impairment (1). A growing number of MRI studies have shown that preterm-born neonates and infants have brain structures with aberrant volumes, morphologies, and networks at term equivalent (2, 3) and school age (4, 5). Studies of resting-state fMRI have also shown that the functional connectivity of the cortex is different in term and preterm infants (6). However, it is a matter of controversy whether neonatal MRI of the brain can predict long-term adverse outcomes, such as minor neurological dysfunction (7,8). Given the fact that preterm birth before 37 wk of gestation accounts for more than 10% of all live births (9), we need a practical and safe method to detect the status of brain development in newborns.The development of the brain involves underlying hemodynamic and metabolic changes (10). Near-infrared spectroscopy (NIRS) has been used to measure cerebral blood concentrations of oxygenated Hb (oxy-Hb) and deoxygenated Hb (deoxy-Hb) at the bedside and estimate cerebral blood volume, oxygen saturation (SO 2 ), cerebral blood flow (CBF), and cerebral metabolic rate of oxygen (CMRO 2 ) in neonates (11,12). Previous studies in pr...

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Spontaneous oscillation of oxy- and deoxy- hemoglobin changes with a phase difference throughout the occipital cortex of newborn infants observed using non-invasive optical topography

Cited by 128 publications

References 19 publications

Developmental Changes of Optical Properties in Neonates Determined by Near-Infrared Time-Resolved Spectroscopy

Developmental Changes of Optical Properties in Neonates Determined by Near-Infrared Time-Resolved Spectroscopy

Development of Global Cortical Networks in Early Infancy

Hemoglobin phase of oxygenation and deoxygenation in early brain development measured using fNIRS

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