Spontaneous orgasms during risperidone treatment in a schizophrenic patient: a case report

Alcántara, A. G.; Nieto, J.

doi:10.1002/(sici)1099-1077(199803)13:2<135::aid-hup966>3.3.co;2-b

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2009

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“…While sexual dysfunction is described as a common adverse effect in the selective serotonin reuptake inhibitors (SSRIs); spontaneous orgasm is an unusual condition described during antidepressive treatment with several different drugs such as venlafaxine and citalopram (Aizenberg, et al, 1995a) bupropion-SR (Aizenberg, et al, 1995b) trazodone (Alcantara and Nieto, 1998), and fluoxetine (Garcia-Campayo, et al, 1995;Morris, 1991).…”

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confidence: 99%

Ziprasidone-induced spontaneous orgasm

et al. 2009

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Neuroleptic treatment in schizophrenic patients has been associated with sexual dysfunction, including impotence and decreased libido. Spontaneous ejaculation without sexual arousal during typical antipsychotic treatment is a rare condition that has been described with zuclopentixol, trifluoperazine, and thiothixene. Here, we are reporting a case of spontaneous orgasm with ziprasidone in a bipolar patient. This patient began to repeatedly experience spontaneous sexual arousal and orgasm, which she had never experienced in the past. Ziprasidone might be causing an increase in sexual orgasm by 5-HT2 receptor antagonism, which preclinical evidence suggests that it facilitates dopamine release in the cortex.

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