Spontaneous Involuntary Disorders of Movement

Family history of primary movement disorders as a predictor for neuroleptic-induced extrapyramidal symptoms

“…Based on a sample that represents a typical cohort of in-patients with acute psychotic symptoms, we observed a lifetime prevalence of extrapyramidal symptoms of 65% and a point prevalence of 34%, comparable to rates reported in large epidemiological studies (Ayd, 1961; Swett, 1975; Owens & Johnstone, 1982). Compared with these studies, the mean age of our patients was low, and the rate of patients ever having been treated with atypical neuroleptics was high (87%).…”

Rich and mad in Victorian England

“…Such a prevalence is in accord with the range of prevalence in modern studies of tardive dyskinesia (e.g. Owens et al 1982). The exact date of onset of symptoms in the Ticehurst cohort could not be clarified in most cases, but the condition was largely seen in the long-stay group.…”

Effect of Methamphetamine on Cognition and Repetitive Motor Behavior of Mice Deficient for Dopamine D2 and D3 Receptors

“…10 The D 1 agonist-induced stereotypy, however, is not accompanied by enhanced striosomal activation, 10 and this finding sheds light onto the mechanism underlying orofacial stereotypies that typically develop in patients treated chronically with neuroleptic drugs. 14 In summary, the present studies indicate a differential and ultimately essential requirement for D 1 -and D 2 -like receptor activation in mediating the effects of METH on cognitive and motor function.…”

“…We recently described stereotypic motor responses to a single dose of the full D 1 agonist SKF 82958 in D 2 mutants that are very similar to those seen after repeated METH administration of wild type and D 3 mutants 10. The D 1 agonist‐induced stereotypy, however, is not accompanied by enhanced striosomal activation,10 and this finding sheds light onto the mechanism underlying orofacial stereotypies that typically develop in patients treated chronically with neuroleptic drugs 14…”