Spontaneous immunomodulation and regulation of angiogenesis and osteogenesis by Sr/Cu-borosilicate glass (BSG) bone cement to repair critical bone defects

Li, Shuaijie; Zhang, Liyan; Liu, Chunyu; Kim, Jua; Su, Kun; Chen, Tingli; Zhao, Luopeng; Lü, Xiaomei; Zhang, Hao; Cui, Yinglin; Cui, Xu; Yuan, Feng; Pan, Haobo

doi:10.1016/j.bioactmat.2022.10.021

Cited by 33 publications

(29 citation statements)

References 59 publications

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“…Angiogenesis is also one of the important issues in the repair of bone defects and is largely regulated by the expression level of VEGF in the microenvironment. , As shown in Figure g–i, there was no significant difference in the expression of VEGF between the diluted MBG extracts and the control group. As for diluted 1V-MBG extracts, there was indistinctive promotion or inhibition at 3rd and 14th day ( P > 0.05) and an obvious promotion at 7th day ( P < 0.05) on VEGF protein secretion compared to the control group, however, there was no significant difference compared with the same dilution ratio MBG extracts ( P > 0.05).…”

Section: Resultsmentioning

confidence: 89%

Vanadium-Doped Mesoporous Bioactive Glass Promotes Osteogenic Differentiation of rBMSCs via the WNT/β-Catenin Signaling Pathway

Cong,

Zhang,

et al. 2023

ACS Appl. Bio Mater.

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Pentavalent vanadium [V(V)] has been studied as bioactive ions to improve the bone defect repair; however, its osteogenic promotion mechanism is still not fully understood so far. In this study, a V-doped mesoporous bioactive glass (V-MBG) was prepared, and its effects on osteogenic differentiation of rat bone marrow mesenchymal stem cells (rBMSCs) and potential signaling pathways were investigated. The physicochemical characterization revealed that the incorporation of V slightly reduced the specific surface area and increased the mesoporous pore size, and the abundant mesopores of V-MBG were beneficial to the sustained dissolution of V(V) ions as well as calcium, silicon, and phosphorus ions. Cell proliferation results indicated that the high dilution ratio (>16) V-MBG extract markedly promoted the proliferation of rBMSCs compared with the control group and the same dilution ratio MBG extract. Compared with the same dilution ratio MBG extract, diluted V-MBG extracts markedly promoted the secretion of alkaline phosphatase (ALP) and osteocalcin (OCN) protein at day 7 but insignificantly stimulated the runt-related transcription factor 2 (RUNX2) and vascular endothelial growth factor (VEGF) protein synthesis. In depth, the diluted V-MBG extracts remarkably up-regulated the expression of WNT/β-catenin pathway direct target genes, including WNT3a, β-catenin, and AXIN2 genes in contrast to the same dilution ratio MBG extracts, suggesting that the released V(V) ions might promote osteogenic differentiation of rBMSCs via the WNT/β-catenin signaling pathway.

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Section: Resultsmentioning

confidence: 89%

Vanadium-Doped Mesoporous Bioactive Glass Promotes Osteogenic Differentiation of rBMSCs via the WNT/β-Catenin Signaling Pathway

Cong,

Zhang,

et al. 2023

ACS Appl. Bio Mater.

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“…Researchers generally believe that osseointegration includes three overlapping and synergistic stages: the immune response of macrophages, the angiogenesis of endothelial cells, and the osteogenesis of osteoblasts. − At the early stage of implantation, macrophages will first gather on the implant surface and initiate an immune response . The polarization state of macrophages, which can be roughly divided into the M1 phenotype (pro-inflammatory) and the M2 phenotype (anti-inflammatory), plays a central role in the immune response.…”

Section: Introductionmentioning

confidence: 99%

Construction of Multifunctional Zinc Ion Sustained-Release Biocoating on the Surface of Carbon Fiber Reinforced Polyetheretherketone with Enhanced Anti-inflammatory Activity, Angiogenesis, and Osteogenesis

Zhao

Dong

Wang

et al. 2023

ACS Appl. Mater. Interfaces

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Current treatments of carbon fiber-reinforced polyetheretherketone (CFRPEEK) as orthopedic implants remain unsatisfactory due to the bioinert surface. The multifunctionalization of CFRPEEK, which endows it with regulating the immune inflammatory response, promoting angiogenesis, and accelerating osseointegration, is critical to the intricate bone healing process. Herein, a multifunctional zinc ion sustained-release biocoating, consisting of a carboxylated graphene oxide, zinc ion, and chitosan layer, covalently grafts on the surface of amino CFRPEEK (CP/GC@Zn/CS) to coordinate with the osseointegration process. The release behavior of zinc ions theoretically conforms to the different demands in the three stages of osseointegration, including the burst release of zinc ions in the early stage (7.27 μM, immunomodulation), continuous release in the middle stage (11.02 μM, angiogenesis), and slow release in the late stage (13.82 μM, osseointegration). In vitro assessments indicate that the multifunctional zinc ion sustained-release biocoating can remarkably regulate the immune inflammatory response, decrease the oxidative stress level, and promote angiogenesis and osteogenic differentiation. The rabbit tibial bone defect model further confirms that, compared to the unmodified group, the bone trabecular thickness of the CP/GC@Zn/CS group increases 1.32-fold, and the maximum push-out force improves 2.05-fold. In this study, a multifunctional zinc ion sustained-release biocoating constructed on the surface of CFRPEEK that conforms to the requirements of different osseointegration stages can be an attractive strategy for the clinical application of inert implants.

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“…3D-printed PCL scaffolds of Plla electrospun microfiber (3D-M-EF) and nanofiber (3D-N-EF) composites have the ability to modulate macrophage M2 polarization, and VEGF and BMP-2 are secreted by M2 to promote angiogenesis and osteogenesis of rat skull defect ( Liu et al, 2021 ). Various metal particles have been studied for the interaction between immune cells and bone regeneration ( Zhao et al, 2021a ; Wan et al, 2022 ; Wu et al, 2022 ; Li et al, 2023 ). Therefore, the intervention of immune microenvironment materials will open a new chapter for the repair strategy of bone regeneration.…”

Section: Introductionmentioning

confidence: 99%

The function of immunomodulation and biomaterials for scaffold in the process of bone defect repair: A review

Dong

Tan

Zhang

et al. 2023

Front. Bioeng. Biotechnol.

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The process of bone regeneration involves the interaction of the skeletal, blood, and immune systems. Bone provides a solid barrier for the origin and development of immune cells in the bone marrow. At the same time, immune cells secrete related factors to feedback on the remodeling of the skeletal system. Pathological or traumatic injury of bone tissue involves changes in blood supply, cell behavior, and cytokine expression. Immune cells and their factors play an essential role in repairing foreign bodies in bone injury or implantation of biomaterials, the clearance of dead cells, and the regeneration of bone tissue. This article reviews the bone regeneration application of the bone tissue repair microenvironment in bone cells and immune cells in the bone marrow and the interaction of materials and immune cells.

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Spontaneous immunomodulation and regulation of angiogenesis and osteogenesis by Sr/Cu-borosilicate glass (BSG) bone cement to repair critical bone defects

Cited by 33 publications

References 59 publications

Vanadium-Doped Mesoporous Bioactive Glass Promotes Osteogenic Differentiation of rBMSCs via the WNT/β-Catenin Signaling Pathway

Vanadium-Doped Mesoporous Bioactive Glass Promotes Osteogenic Differentiation of rBMSCs via the WNT/β-Catenin Signaling Pathway

Construction of Multifunctional Zinc Ion Sustained-Release Biocoating on the Surface of Carbon Fiber Reinforced Polyetheretherketone with Enhanced Anti-inflammatory Activity, Angiogenesis, and Osteogenesis

The function of immunomodulation and biomaterials for scaffold in the process of bone defect repair: A review

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