2007
DOI: 10.1038/nchembio.2007.18
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: The removal of intervening sequences from transcripts is catalyzed by the spliceosome, a multicomponent complex that assembles on the newly synthesized pre-mRNA. Pre-mRNA translation in the cytoplasm leads to the generation of aberrant proteins that are potentially harmful. Therefore, tight control to prevent undesired pre-mRNA export from the nucleus and its subsequent translation is an essential requirement for reliable gene expression. Here, we show that the natural product FR901464 (1) and its methylated d… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

45
691
0
2

Year Published

2009
2009
2023
2023

Publication Types

Select...
4
2

Relationship

0
6

Authors

Journals

citations
Cited by 569 publications
(738 citation statements)
references
References 47 publications
45
691
0
2
Order By: Relevance
“…These data suggest that SF3B1 mutations may confer reduced sensitivity to drug induced apoptosis supporting previous reports with fludarabine. 51 The binding of SSA to SF3B1 inhibits pre-RNA splicing 16 but also induces changes in alternative splicing. 52 We have demonstrated in CLL cells that SSA promotes alternative-splicing of MCL-1.…”
Section: Discussionmentioning
confidence: 99%
See 4 more Smart Citations
“…These data suggest that SF3B1 mutations may confer reduced sensitivity to drug induced apoptosis supporting previous reports with fludarabine. 51 The binding of SSA to SF3B1 inhibits pre-RNA splicing 16 but also induces changes in alternative splicing. 52 We have demonstrated in CLL cells that SSA promotes alternative-splicing of MCL-1.…”
Section: Discussionmentioning
confidence: 99%
“…16 Meayamycin B was produced by the Koide group (University of Pittsburgh, USA). 20 ABT-199 and ABT-263 were purchased from Selleckchem (USA).…”
Section: Reagents and Antibodiesmentioning
confidence: 99%
See 3 more Smart Citations