Splenic abscess caused by MRSA developing in an infarcted area: case report and literature review

Arslan, Ferhat; Batırel, Ayşe; Tabak, Fehmı; Mert, Ali

doi:10.1007/s10156-011-0247-9

Cited by 7 publications

(6 citation statements)

References 17 publications

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“…The abscess is composed of bacteria and dead and live neutrophils encapsulated in collagen, fibrin, and other fibrous materials that contain bacteria at the site of infection and prevent dissemination to the bloodstream and other organs [ 16 ]. While bacterial products are essential components of a compact and well-organized abscess, the host-derived cellular sources and molecular programs t that promote abscess formation are not well understood [ 17 , 18 ]. Therefore, therapeutic strategies to improve abscess formation along with enhancing antimicrobial effector functions are highly desirable.…”

Section: Introductionmentioning

confidence: 99%

Macrophage-derived LTB4 promotes abscess formation and clearance of Staphylococcus aureus skin infection in mice

et al. 2018

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The early events that shape the innate immune response to restrain pathogens during skin infections remain elusive. Methicillin-resistant Staphylococcus aureus (MRSA) infection engages phagocyte chemotaxis, abscess formation, and microbial clearance. Upon infection, neutrophils and monocytes find a gradient of chemoattractants that influence both phagocyte direction and microbial clearance. The bioactive lipid leukotriene B4 (LTB4) is quickly (seconds to minutes) produced by 5-lipoxygenase (5-LO) and signals through the G protein-coupled receptors LTB4R1 (BLT1) or BLT2 in phagocytes and structural cells. Although it is known that LTB4 enhances antimicrobial effector functions in vitro, whether prompt LTB4 production is required for bacterial clearance and development of an inflammatory milieu necessary for abscess formation to restrain pathogen dissemination is unknown. We found that LTB4 is produced in areas near the abscess and BLT1 deficient mice are unable to form an abscess, elicit neutrophil chemotaxis, generation of neutrophil and monocyte chemokines, as well as reactive oxygen species-dependent bacterial clearance. We also found that an ointment containing LTB4 synergizes with antibiotics to eliminate MRSA potently. Here, we uncovered a heretofore unknown role of macrophage-derived LTB4 in orchestrating the chemoattractant gradient required for abscess formation, while amplifying antimicrobial effector functions.

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Section: Introductionmentioning

confidence: 99%

Macrophage-derived LTB4 promotes abscess formation and clearance of Staphylococcus aureus skin infection in mice

et al. 2018

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“…Splenic abscess can also occur in a previously infarcted area by direct seeding of the spleen from an adjacent infectious process. [13] It is our belief that the large splenic infarction in relation to the nearby contamination from the gastric leak predisposed to splenic abscess in our patient.…”

Section: Discussionmentioning

confidence: 60%

“…An infarcted splenic area may progress into a subcapsular hematoma, get infected and progress into an abscess, or may even rupture into the abdomen. [13] Larger volumes of infarction lead to greater rates of complications. To our knowledge, only two cases of splenic abscess following LSG have been reported and attributed to splenic infarct complications.…”

Section: Discussionmentioning

confidence: 99%

Splenic abscess secondary to sleeve gastrectomy leak

Shanti¹

2017

Laparosc Endosc Surg Sci

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Sleeve gastrectomy is currently a stand-alone bariatric procedure with a low complication profile. A rare complication of leak following sleeve gastrectomy was reported in this study. A 34-year-old male patient with body mass index of 69.9 was admitted to hospital 4 months after sleeve gastrectomy with epigastric pain and fever, and leak at the gastroesophageal junction was observed on computed tomography scan. In addition, he had splenic vein thrombosis with infected partial splenic infarction with abscess formation. Endoscopic stent was used to cover the leak and percutaneous drainage of the splenic abscess was performed. Partial infarction of the spleen is not a rare occurrence after laparoscopic sleeve gastrectomy. However, abscess development is extremely rare. Familiarity with these rare complications will allow for prompt diagnosis and treatment.

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“…Splenic infarction may have no clinical relevance in the vast majority of patients [14][15][16] and it usually resolved spontaneously. When symptomatic, it often presents with vague or nonspecific signs and symptoms, including left upper quadrant pain, fever, nausea and vomiting, associated with leukocytosis and may be difficult to differentiate from the leakage [17]. More seriously it can rarely progress to a splenic abscess in the presence of a gastric leak or systemic infection as the case in our patient.…”

Section: Discussionmentioning

confidence: 71%

Splenic Abscess: A Rare Complication of Sleeve Gastrectomy: A Case Report and literature Review.

Yassin¹

2020

JCRR

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Splenic abscess is a rare complication of laparoscopic sleeve gastrectomy (LSG) with only a few cases reported in the literature.Here we report a 41-year-old healthy female with a BMI of 42 who had laparoscopic sleeve gastrectomy complicated with splenic vein thrombosis and splenic infarctions in the early postoperative period and progressed to a splenic abscess with a latediagnosed leakage from the gastric remnant. She was treated with laparoscopic splenectomy and a Roux-en-Y esophagojejunostomy.

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Splenic abscess caused by MRSA developing in an infarcted area: case report and literature review

Cited by 7 publications

References 17 publications

Macrophage-derived LTB4 promotes abscess formation and clearance of Staphylococcus aureus skin infection in mice

Macrophage-derived LTB4 promotes abscess formation and clearance of Staphylococcus aureus skin infection in mice

Splenic abscess secondary to sleeve gastrectomy leak

Splenic Abscess: A Rare Complication of Sleeve Gastrectomy: A Case Report and literature Review.

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