SPIO-labeled Yttrium Microspheres for MR Imaging Quantification of Transcatheter Intrahepatic Delivery in a Rodent Model

Li, Weiguo; Zhang, Zhuoli; Gordon, Andrew C.; Chen, Jeane; Nicolai, J.; Lewandowski, Robert J.; Omary, Reed A.; Larson, Andrew C.

doi:10.1148/radiol.2015150315

Cited by 12 publications

(7 citation statements)

References 16 publications

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“…At present, the application of the MR R 2 * imaging sequence, which is a reliable and noninvasive tool to evaluate the iron content in living tissues, can sensitively detect changes of magnetic environment caused by the change of iron content in the body. It has been confirmed that there is a high correlation between iron content in the tissue and R 2 * value (Wood et al., 2005 ; Idilman et al., 2016 ; Li et al., 2016c ). As shown in Figure 4(a) , the larger the orange-red region of the tumor becomes, the higher the R 2 * value of the tumor tissue will be.…”

Section: Resultsmentioning

confidence: 84%

Designing multifunctional cancer-targeted nanosystem for magnetic resonance molecular imaging-guided theranostics of lung cancer

Gao

Mei

et al. 2018

Drug Delivery

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The integration of diagnosis and therapy is an effective way to improve therapeutic effects for cancer patients, which has acquired widely attentions from researchers. Herein, a multifunctional drug-loaded nanosystem (F/A-PLGA@DOX/SPIO) has been designed and synthesized to reduce the side effects of traditional chemotherapy drugs and realize simultaneous tumor diagnosis and treatment. The surface modification of folic acid (FA) and activatable cell-penetrating peptide (ACPP) endows the nanosystem with excellent cancer targeting capabilities, thus reducing toxicity to normal organs. Besides, the F/A-PLGA@DOX/SPIO nanosystem can serve as an excellent magnetic resonance imaging (MRI) T2-negative contrast agent. More importantly, according to in vitro experiments, the F/A-PLGA@DOX/SPIO nanosystem can promote the overproduction of reactive oxygen species (ROS) within A549 lung cancer cells, inducing cell apoptosis, greatly enhancing the antineoplastic effect. Furthermore, with the help of MRI technology, the targeting imaging of the F/A-PLGA@DOX/SPIO nanosystem within tumors and the dynamic monitoring of medicine efficacy can be realized. Therefore, this study provided a multifunctional drug-loaded F/A-PLGA@DOX/SPIO targeted nanosystem for magnetic resonance molecular imaging-guided theranostics, which has excellent potential for the application in tumor diagnosis and therapy.

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Section: Resultsmentioning

confidence: 84%

Designing multifunctional cancer-targeted nanosystem for magnetic resonance molecular imaging-guided theranostics of lung cancer

Gao

Mei

et al. 2018

Drug Delivery

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show abstract

“…With reference to the relevant literature 13 – 16 , and combined with the previous pharmacokinetics and toxicological data 5 , 6 , the probe concentration (in terms of iron content) used for the experiments were 6 mg·kg −1 , 12 mg·kg −1 , 18 mg·kg −1 , 24 mg·kg −1 and 30 mg·kg −1 . Correspondingly, these tumor-bearing nude mice were randomly divided into five groups, with six mice each group.…”

Section: Methodsmentioning

confidence: 99%

Optimal scanning concentration of MR imaging for tumor-bearing nude mice with SPIO-shRNA molecular probe

Zhang

Yang

Wen

2020

Sci Rep

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The objective of this study is to investigate the signal changes and optimal scanning concentration of MRI in tumor tissues of tumor-bearing nude mice by SPIO-shRNA molecular probes. 30 BALB/c tumor-bearing nude mice were randomly divided into 5 groups with 6 mice in each group. At the given scanning time (before and 27 h after injection), the caudal vein was respectively injected with iron content of 6 mg·kg−1, 12 mg·kg−1, 18 mg·kg−1, 24 mg·kg−1, and 30 mg·kg−1, and MR examination was simultaneously performed to measure signal intensity changes of tumor tissue and contralateral muscle tissue in each concentration group. After each examination above, the nude mice were sacrificed immediately, and the tumor and muscle tissues were removed for HE and Prussian blue staining,and observed under light microscope. Nude mice in 6 mg, 12 mg and 18 mg groups all survived after probe injection, but some nude mice died in 24 mg and 30 mg groups after probe injection or during scanning. The signal changes of T2WI and T2*WI sequences were the most obvious in MR scanning sequences. Compared with other groups, the signal intensity of the tumor tissue in 18 mg, 24 mg and 30 mg groups were most obvious (P < 0.05), while the 18 mg, 24 mg and 30 mg groups reached no statistical difference (P > 0.05 ); HE staining indicated that structural disorder of tumor tissue as well as increase of nuclear atypia. Prussian Blue staining showed that blue-stained iron particles were present in each experimental group,and the most densely distributed were in 18 mg,24 mg and 30 mg groups. Tumor tissue could be well labeled with SPIO-shRNA molecular probes, and the optimal MR scanning concentration (iron content) is 18 mg·kg−1.

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“…Noninvasive methods for quantifying SPIO concentrations in vivo include PET imaging of radiolabeled SPIO 9,10 and various MR imaging techniques including widely used R2* relaxometry using T2*-weighted MRI 11 . R2* measurement was shown to be linear with the concentration of SPIO 12 , and has been applied to various preclinical models of disease [13][14][15] . However, as R2*-based estimations of SPIO concentration are dependent on imaging parameters as well as the SPIO's local tissue environment and chemical composition 13,16,17 , it may not be suitable for quantification of an absolute amount of SPIO.…”

Section: The Use Of Magnetic Fluid Hyperthermia (Mfh) For Cancer Thermentioning

confidence: 99%

Validation of MRI quantitative susceptibility mapping of superparamagnetic iron oxide nanoparticles for hyperthermia applications in live subjects

Deh

Zaman

Vedvyas

et al. 2020

Sci Rep

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The use of magnetic fluid hyperthermia (MFH) for cancer therapy has shown promise but lacks suitable methods for quantifying exogenous irons such as superparamagnetic iron oxide (SPIO) nanoparticles as a source of heat generation under an alternating magnetic field (AMF). Application of quantitative susceptibility mapping (QSM) technique to prediction of SPIO in preclinical models has been challenging due to a large variation of susceptibility values, chemical shift from tissue fat, and noisier data arising from the higher resolution required to visualize the anatomy of small animals. In this study, we developed a robust QSM for the SPIO ferumoxytol in live mice to examine its potential application in MFH for cancer therapy. We demonstrated that QSM was able to simultaneously detect high level ferumoxytol accumulation in the liver and low level localization near the periphery of tumors. Detection of ferumoxytol distribution in the body by QSM, however, required imaging prior to and post ferumoxytol injection to discriminate exogenous iron susceptibility from other endogenous sources. Intratumoral injection of ferumoxytol combined with AMF produced a ferumoxytol-dose dependent tumor killing. Histology of tumor sections corroborated QSM visualization of ferumoxytol distribution near the tumor periphery, and confirmed the spatial correlation of cell death with ferumoxytol distribution. Due to the dissipation of SPIOs from the injection site, quantitative mapping of SPIO distribution will aid in estimating a change in temperature in tissues, thereby maximizing MFH effects on tumors and minimizing side-effects by avoiding unwanted tissue heating.

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SPIO-labeled Yttrium Microspheres for MR Imaging Quantification of Transcatheter Intrahepatic Delivery in a Rodent Model

Cited by 12 publications

References 16 publications

Designing multifunctional cancer-targeted nanosystem for magnetic resonance molecular imaging-guided theranostics of lung cancer

Designing multifunctional cancer-targeted nanosystem for magnetic resonance molecular imaging-guided theranostics of lung cancer

Optimal scanning concentration of MR imaging for tumor-bearing nude mice with SPIO-shRNA molecular probe

Validation of MRI quantitative susceptibility mapping of superparamagnetic iron oxide nanoparticles for hyperthermia applications in live subjects

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