␣ 2 -Adrenergic receptors (ARs) 1 are members of the large superfamily of G protein-coupled receptors that contain seven putative transmembrane spanning regions. There are three ␣ 2 -AR subtypes (␣ 2A , ␣ 2B , and ␣ 2C ), each of which is activated by the endogenous catecholamines, epinephrine and norepinephrine, and performs multiple physiological functions via pertussis toxin-sensitive G i /G o proteins (1). Cellular signaling pathways regulated by ␣ 2A -AR in native cells include inhibition of adenylyl c…
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