2010
DOI: 10.1002/mds.23324
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Abstract: Spinocerebellar ataxia type 10 (SCA10) is an autosomal dominant disorder caused by an ATTCT repeat intronic expansion in the SCA10 gene. SCA 10 has been reported in Mexican, Brazilian, Argentinean and Venezuelan families. Its phenotype is overall characterized by cerebellar ataxia and epilepsy. Interestingly, Brazilian patients reported so far showed pure cerebellar ataxia, without epilepsy. Here, authors provide a systematic analysis of the presence, frequency and electroencephalographic presentation of epile… Show more

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Cited by 38 publications
(44 citation statements)
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“…The gene is highly expressed in the olivocerebellar regions, its function is unknown (Table 1) [103,198]. In healthy persons, the gene comprises 10-12 ATTCT-repeats, while pathological repeat expansions can reach into the thousands [97,170]. SCA10 manifests with ataxia, dysarthria, dysphagia, oculomotor dysfunction, ocular dyskinesia, pyramidal signs, psychiatric symptoms as well as cognitive impairments (Table 1).…”
Section: Sca10mentioning
confidence: 98%
See 1 more Smart Citation
“…The gene is highly expressed in the olivocerebellar regions, its function is unknown (Table 1) [103,198]. In healthy persons, the gene comprises 10-12 ATTCT-repeats, while pathological repeat expansions can reach into the thousands [97,170]. SCA10 manifests with ataxia, dysarthria, dysphagia, oculomotor dysfunction, ocular dyskinesia, pyramidal signs, psychiatric symptoms as well as cognitive impairments (Table 1).…”
Section: Sca10mentioning
confidence: 98%
“…SCA10 manifests with ataxia, dysarthria, dysphagia, oculomotor dysfunction, ocular dyskinesia, pyramidal signs, psychiatric symptoms as well as cognitive impairments (Table 1). About half of the patients display epilepsy [163,170,198]. Disease onset is in childhood or adulthood.…”
Section: Sca10mentioning
confidence: 99%
“…Subtype prevalence rates vary among geographic regions. For example, M A N U S C R I P T A C C E P T E D (Arruda et al, 1991;Klockgether, 2000;Teive, 2009;Teive et al, 2010;Magana et al, 2012).…”
Section: Introductionmentioning
confidence: 94%
“…SCA cases can be classified according to genetic inheritance as autosomal recessive, autosomal dominant, X-linked, or mitochondrial (Teive et al, 2010).…”
Section: Introductionmentioning
confidence: 99%
“…For example, the highest prevalence rates of SCA 2 are found in Cuba, India, England, France, and the USA, whereas SCA 3 is most prevalent in Portugal, Brazil, Germany, Japan, and China. Meanwhile, SCA 6 is particularly prevalent in Japan, Australia, and Germany, SCA 7 is most prevalent in Sweden, Finland, the USA, and China, and SCA 10 cases are concentrated in Mexico and Brazil 2,12,13 . Body balance depends on the integrity of the: vestibular system (VS) (labyrinth, vestibulocochlear nerve, nuclei, pathways and connections to the central nervous system -CNS); somatosensory system (sensory receptors located in tendons), muscles, joints and vision 14 .…”
mentioning
confidence: 99%