Spine Deformity Correction in Marfan Syndrome

Jones, Kevin B.; Erkula, Gürkan; Sponseller, Paul D.; Dormans, John P.

doi:10.1097/00007632-200209150-00008

Cited by 100 publications

(61 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4,16,17 The diagnosis of infection is difficult to establish but is suggested by pain, 18 the presence of a sinus tract, persistent or late postoperative wound drainage, erythema, wound dehiscence, positive culture from a wound aspirate, instrumentation failure/pseudoarthrosis and pathologic confirmation of the presence of inflammatory cells and/or the offending organism(s). 1,3,5,6,19 Staphylococcus aureus 1,12,15 and S. epidermidis 2,5,20 have been reported to be the most common causative organisms. A high erythrocyte sedimentation rate (ESR) has also been reported to be associated with late infection.…”

mentioning

confidence: 99%

Deep wound infection following pediatric scoliosis surgery: incidence and analysis of risk factors

Aleissa¹

2011

Can J Surg

View full text Add to dashboard Cite

Background:Deep wound infection after spinal surgery is a severe complication that often requires prolonged medical and surgical management. It can compromise the outcome of the deformity correction, especially in patients requiring surgical intervention with subsequent removal of implants. Ascertaining the incidence and risk factors leading to infection may help to prevent this problem. Methods:We reviewed the hospital charts of all patients who underwent spinal deformity correction from 1996 to 2005. Results:In all, 227 patients were identified (139 idiopathic, 57 neuromuscular, 8 syndromic, 6 congenital, 17 other); 191 patients were treated with posterior instrumentation and fusion, 11 with anterior-only procedures and 24 with combined anterior and posterior procedures. Final follow-up ranged from 1 to 9.5 years. Infection developed in 14 patients. The overall incidence of infection was 6.2%. Drainage and back pain were the most common presenting symptoms. The incidence of infection was higher among patients with nonidiopathic diagnoses (risk ratio [RR] 8.65, p < 0.001). Use of allograft bone was associated with a higher rate of infection (RR 9.66, p < 0.001) even when stratified by diagnosis (nonidiopathic diagnoses, RR 7.6, p = 0.012). Higher volume of instrumentation was also a risk factor for infection (p = 0.022). Coagulasenegative Staphyloccocus was the most commonly identified organism, followed by Propionibacterium acnes and Pseudomonas. Conclusion:Development of infection following scoliosis surgery was found to be associated with several risk factors, including a nonidiopathic diagnosis, the use of allograft and a higher volume of instrumentation. Preventative measures addressing these factors may decrease the rate of infection.Contexte : L'infection profonde de la plaie après une intervention chirurgicale à la colonne est une complication grave qui nécessite souvent un traitement médical et chirurgical prolongé. L'infection peut compromettre le résultat de la correction d'une malformation, surtout chez les patients qui doivent subir une autre intervention chirurgicale pour retirer des implants. La détermination de l'incidence et des facteurs de risque d'infection pourrait aider à éviter le problème.Méthodes : Nous avons examiné les dossiers d'hôpital de tous les patients qui ont subi, de 1996 à 2005, une intervention chirurgicale à la colonne visant à corriger une malformation.

show abstract

mentioning

confidence: 99%

Deep wound infection following pediatric scoliosis surgery: incidence and analysis of risk factors

Aleissa¹

2011

Can J Surg

View full text Add to dashboard Cite

show abstract

“…To date, only three series have been published [2][3][4]. It has been shown that the natural history of the scoliosis associated with MFS is unique and does not resemble that in AIS; it is often more severe [2] in MFS patients, and the King's guidelines used to determine the extent of the arthrodesis in AIS [16,17] does not fit the scoliosis associated with MFS [5][6][7]. A subset of patients with both juvenile and adolescent ''idiopathic'' scoliosis may have an underlying condition that may cause the scoliosis.…”

Section: Discussionmentioning

confidence: 99%

Scoliotic curve patterns in patients with Marfan syndrome

Glard

Launay

Edgard-Rosa

et al. 2008

Journal of Children's Orthopaedics

View full text Add to dashboard Cite

“…This is the ratio between the dural sac diameter (DSD) measured on the midline sagittal image and the vertebral body diameter (VBD) at the same level (63). Further signs include scalloping of the vertebrae, and perineural or Tarlov cysts (cystic dilation containing spinal fluid along the nerve root) (64).…”

Section: Diagnosismentioning

confidence: 99%

Non-cardiac manifestations of Marfan syndrome

Child

2017

Ann. Cardiothorac. Surg.

View full text Add to dashboard Cite

Because of the widespread distribution of fibrillin 1 in the body, Marfan syndrome (MFS) affects virtually every system. The expression of this single dominantly inherited gene is variable within a family, and between families. There is some genotype-phenotype correlation which is helpful in guiding long-term prognosis, and management. In general gene mutations have been reported in clusters, with those having mainly ocular manifestations occurring in exons 1 to 15 of this 65-exon gene; those causing cardiac problems often involving cysteine replacement in a calcium binding EGF-like sequence; the most severe mutations occurring in exons 25-32, causing neonatal MFS diagnosed at birth, and severe enough to cause death frequently before the age of 2. Other correlations will certainly be found in future. This condition is progressive, and the manifestations unfold according to age. For example, if the lens is going to dislocate this usually occurs by age 10; scoliosis usually presents itself between the ages of 8 and 15; height should be monitored carefully between the onset of puberty and cessation of growth approximately age 17 or 18. Holistic care should be offered by one doctor who oversees the patient's welfare. This should be a paediatrician, paediatric cardiologist, or general practitioner in the case of an affected child. Thereafter, the physician in charge of the most seriously affected system should be aware that other systems need to be managed through a referral network.

show abstract

Spine Deformity Correction in Marfan Syndrome

Cited by 100 publications

References 35 publications

Deep wound infection following pediatric scoliosis surgery: incidence and analysis of risk factors

Deep wound infection following pediatric scoliosis surgery: incidence and analysis of risk factors

Scoliotic curve patterns in patients with Marfan syndrome

Non-cardiac manifestations of Marfan syndrome

Contact Info

Product

Resources

About