Spindle-cell Proliferative Disease in Broiler Chickens Suspected of Marek's Disease at Meat Inspection

Systemic Spindle-Cell Proliferative Disease in Broiler Chickens

“…67(1): [13][14][15][16][17][18] 2005 Spindle-cell proliferative disease (SPD) in broiler chickens is detected in some broiler carcasses suspected of Marek's disease (MD) at meat inspection in Japan [7,8]. Microscopically, the proliferative lesions of SPD are observed in the Glisson's sheath of the liver and in the white pulp and around the sheathed arteries of the spleen [7,8]. The proliferating cells are mainly spindle-shaped or pleomorphic, and variable in size, with abundant eosinophilic cytoplasm [7,8].…”

“…The lesions of SPD can be transmitted by intramuscular inoculation of the affected organ homogenate to specific-pathogen free (SPF) chicks [7,8]. Although subgroup J avian leukosis virus (ALV) was suspected as the etiologic agent of SPD based on reverse transcriptasepolymerase chain reaction analyses, we have not yet been able to prove such an association [7,8].SPD resembles histiocytic sarcomatosis (HS) and multicentric histiocytosis (MH) in the macroscopical and microscopical findings [1,3,4,7,8]. In HS and MH, the lesions are observed in several organs and the origin of the proliferating cells is the histiocyte [1,3,4].…”

“…The etiology of HS is described as subgroup J ALV [1], whereas that of MH has not been ascertained [2]. It remains to be seen whether SPD is related to HS and/or MH [7,8].The aims of this study were to determine the histopathological distribution of the proliferative lesions in broiler carcasses suspected of SPD at meat inspection, and to reproduce this disease in SPF chickens by inoculation of homogenate of the affected spleens, and to consider the possible etiology of SPD. …”

“…Microscopically, the proliferative lesions of SPD are observed in the Glisson's sheath of the liver and in the white pulp and around the sheathed arteries of the spleen [7,8]. The proliferating cells are mainly spindle-shaped or pleomorphic, and variable in size, with abundant eosinophilic cytoplasm [7,8]. The lesions of SPD can be transmitted by intramuscular inoculation of the affected organ homogenate to specific-pathogen free (SPF) chicks [7,8].…”

“…The etiology of HS is described as subgroup J ALV [1], whereas that of MH has not been ascertained [2]. It remains to be seen whether SPD is related to HS and/or MH [7,8].…”