Spinal Myoclonus after Subarachnoid Anesthesia with Bupivacaine

Abstract

After ruling out all possible causes, the diagnosis of spinal myoclonus after spinal anesthesia with bupivacaine was made by exclusion.

Progression of pre-eclampsia to eclampsia under spinal anaesthesia

“…[2] ‘Spinal myoclonus associated with subarachnoid anesthesia with bupivacaine has been reported,[7] both in Caucasians[8] and patients of African origin. [9] Whereas, our patient had generalized tonic-clonic seizures, spinal myoclonus associated with subarachnoid anesthesia with bupivacaine affected the lower limbs only.’ When this patient with severe pre-eclampsia consented to undergo an emergency cesarean section, she was counseled for spinal anesthesia, which she also accepted.…”

Myoclonus following spinal anaesthesia - case report of a rare complication

“…1 The pathophysiology of spinal myoclonus seems to be an abnormal hyperactivity of the local dorsal horn interneurons with loss of inhibition of suprasegmental descending pathways usually restricted to a muscle, or a group of muscles. 3 In majority of myoclonus, the pathophysiology is unclear, but there is possibility of abnormalities or deficiencies in neurotransmitter receptors, including serotonin, GABA, opiate, glycine, and dopamine. 2 Spinal myoclonus appears as stimulus-sensitive.…”

“…The reports of myoclonus following spinal anaesthesia in adults are extremely rare. 3,4 We herein report a case of myoclonus following spinal anaesthesia which was successfully managed.…”

Propriospinal myoclonus: The spectrum of clinical and neurophysiological phenotypes

“…Different pharmacological treatments have also been associated with PSM onset, i.e., interferon-alpha [30], intrathecal bupivacaine [31,32], ciprofloxacin [33] and cannabis [34].…”