Spinal histamine H4 receptor mediates chronic pruritus via p‐ERK in acetone–ether–water (AEW)‐induced dry skin mice
Ting‐Ting Wang,
Zi‐Yang Li,
Dan‐Dan Hu
et al.
Abstract:Dry skin is common to many pruritic diseases and is difficult to improve with oral traditional antihistamines. Recently, increasing evidence indicated that histamine H4 receptor (H4R) plays an important role in the occurrence and development of pruritus. Extracellular signal‐regulated kinase (ERK) phosphorylation activation in the spinal cord mediates histamine‐induced acute and choric itch. However, whether the histamine H4 receptor regulates ERK activation in the dry skin itch remains unclear. In the study, … Show more
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