Spinal Epidural Abscess Patients Have Higher Modified Frailty Indexes Than Back Pain Patients on Emergency Room Presentation: A Single-Center Retrospective Case-Control Study

Dominguez, Jose F.; Shah, Smit; Ampie, Leonel; Chen, Xintong; Li, Boyi; Ng, Christina; Feldstein, Eric; Wainwright, John V.; Schmidt, Meic H.; Cole, Chad; Koo, Donna C.; Chadha, Bhawneet; Lee, Joo Sang; Yarrabothula, Akshitha; Rao, Nirupama; Adkoli, Anusha; Miller, Ivan; Gandhi, Chirag D.; Al‐Mufti, Fawaz; Santarelli, Justin; Bowers, Christian A.

doi:10.1016/j.wneu.2021.06.035

Cited by 5 publications

(2 citation statements)

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“…This score has been stratified to classify a patient's level of frailty using different cut off points. [15][16][17]38 Frailty was dichotomized based on the mean mFI and one standard deviation above. A frail state was defined when mFI was 2 or greater in our patient cohort.…”

Section: Variablesmentioning

confidence: 99%

“…It is an increasingly common variable of interest across disciplines and its usefulness to predict outcomes has been studied extensively. [14][15][16][17][18][19][20][21][22] Past literature has demonstrated that frailty is an independent predictor for increased AKI incidence in elderly patients, and non-frail patients with AKI are also more at risk to develop frailty. [23][24][25] A few studies show frailty to be associated with poor outcomes in aSAH patients, but its association may be relatively weak compared to age.…”

Section: Introductionmentioning

confidence: 99%

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Utility of frailty as a predictor of acute kidney injury in patients with aneurysmal subarachnoid hemorrhage

Dominguez

Hosein-Woodley

et al. 2022

Interv Neuroradiol

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Introduction Acute kidney injury (AKI) is associated with poor outcome in aneurysmal subarachnoid hemorrhage patients (aSAH). Frailty has recently been demonstrated to correlate with elevated mortality and morbidity; its impact on predicting AKI and mortality in aSAH patients has not been investigated. Objective Evaluating risk factors and predictors for AKI in aSAH patients. Methods aSAH patients from a single-center's prospectively maintained database were retrospectively evaluated for development of AKI within 14 days of admission. Baseline demographic and clinical characteristics were collected. The effect of frailty and other risk factors were evaluated. Results Of 213 aSAH patients, 53 (33.1%) were frail and 12 (5.6%) developed AKI. Admission serum creatinine (sCr) and peak sCr within 48 h were higher in frail patients. AKI patients showed a trend towards higher frailty. Mortality was significantly higher in AKI than non-AKI aSAH patients. Frailty was a poor predictor of AKI when controlling for Hunt and Hess (HH) grade or age. HH grade ≥ 4 strongly predicted AKI when controlling for frailty. Conclusion AKI in aSAH patients carries a poor prognosis. The HH grade appears to have superior utility as a predictor of AKI in aSAH patients than mFI.

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Section: Variablesmentioning

confidence: 99%