Sphingosine‐1‐phosphate signalling in the heart: exploring emerging perspectives in cardiopathology
Franck Phan,
Olivier Bourron,
Fabienne Foufelle
et al.
Abstract:Cardiometabolic disorders contribute to the global burden of cardiovascular diseases. Emerging sphingolipid metabolites like sphingosine‐1‐phosphate (S1P) and its receptors, S1PRs, present a dynamic signalling axis significantly impacting cardiac homeostasis. S1P's intricate mechanisms extend to its transportation in the bloodstream by two specific carriers: high‐density lipoprotein particles and albumin. This intricate transport system ensures the accessibility of S1P to distant target tissues, influencing se… Show more
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