2011
DOI: 10.1111/j.1476-5381.2010.01118.x
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Abstract: Sphingosine-1-phosphate (S1P) is a pleiotropic bioactive lipid thought to be dysregulated in a variety of disease conditions. In this review, we discuss the roles of S1P in cancer and in wet age-related macular degeneration. We also explore potential treatment strategies for these disorders, including the utility of anti-S1P antibodies acting as molecular sponges to neutralize dysregulated S1P in relevant tissues. AbbreviationsAMD, age-related macular degeneration; CNV, choroidal neovascularization; GLP, good… Show more

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