Journal of Cell Biology volume 217, issue 2, P495-505 2018 DOI: 10.1083/jcb.201708068 View full text
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Francisco Piña, Fumi Yagisawa, Keisuke Obara, J.D. Gregerson, Akio Kihara, Maho Niwa

Abstract: In yeast, the ER stress surveillance (ERSU) pathway ensures that daughter cells inherit a functional ER during ER stress. Piña et al. show that phytosphingosine (PHS) levels increase during ER stress and PHS alone is sufficient to activate the hallmarks of ERSU activation: cER inheritance block, septin mislocalization, and Slt2 phosphorylation.