2017
DOI: 10.1007/s11916-017-0626-8
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Abstract: Studies have demonstrated that SPG blockade and neurostimulation can provide pain relief in patients with cluster headaches, migraines, and other trigeminal autonomic cephalalgias. Patients with these conditions showed varying levels and duration of pain relief from SPG blockade. The efficacy of SPG blockade could be related to the different techniques targeting the SPG and choice of therapeutic agents. Based on current studies, SPG blockade is a safe and effective treatment for chronic headaches such as clust… Show more

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Cited by 46 publications
(23 citation statements)
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References 36 publications
(44 reference statements)
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“…Several analyses employed the use of sphenopalatine ganglion (SPG) blocks, as this method targets the sensory innervation to the nasal mucosa . These blocks have demonstrated value in the management of a variety of etiologies, including chronic headaches, trigeminal neuralgia, and postherpetic neuralgia . Importantly, several studies utilizing agents delivered via SPG blocks demonstrated efficacy in minimizing subsequent analgesia requirements.…”
Section: Discussionmentioning
confidence: 99%
“…Several analyses employed the use of sphenopalatine ganglion (SPG) blocks, as this method targets the sensory innervation to the nasal mucosa . These blocks have demonstrated value in the management of a variety of etiologies, including chronic headaches, trigeminal neuralgia, and postherpetic neuralgia . Importantly, several studies utilizing agents delivered via SPG blocks demonstrated efficacy in minimizing subsequent analgesia requirements.…”
Section: Discussionmentioning
confidence: 99%
“…Activation of the pathway stimulates release of vasoactive peptides, leading to extravasation of plasma proteins and neurogenic inflammation. 5 Clinically, activation of this pathway can manifest as a variety of autonomic symptoms, including lacrimation, nasal congestion and rhinorrhea, conjunctival injection, periorbital edema, and craniofacial sweating. Trigeminal autonomic cephalalgias (TACs) are a collection of headache disorders that share these autonomic symptoms.…”
Section: Pathophysiology and Pain Syndromesmentioning
confidence: 99%
“…The intimate involvement of the SPG in the neural pathways associated with TACs has made it a notable target for clinicians treating patients with these disorders. 5 CH is the most common and well studied of the TACs. CH is characterized by unilateral headache pain in the trigeminal V1 dermatome and is classically associated with parasympathetic symptoms of lacrimation, nasal congestion, and conjunctival injection.…”
Section: Pathophysiology and Pain Syndromesmentioning
confidence: 99%
“…Transitional treatment is fast acting, but the effect usually lasts only a couple of weeks; it can bridge the gap between the start of prophylactic medication and adequate drug titration. Current therapy mainly consists of pharmacotherapy, but neuromodulatory treatment methods such as occipital nerve stimulation [8,9], non-invasive vagal nerve stimulation [10], sphenopalatine ganglion stimulation [11] and blockade [12] and local infiltration with anaesthetics and corticosteroids are becoming more and more available with increasing evidence of efficacy.…”
Section: Introductionmentioning
confidence: 99%