Sperm retrieval rate and pregnancy rate in infertile couples undergoing in-vitro fertilisation and testicular sperm extraction for non-obstructive azoospermia in Hong Kong

Ko, Jennifer K.Y.; Chai, Joyce; Lee, Vivian CY; Li, Raymond HW; Lau, Esther Yuet Ying; Ho, K L; Tam, Po‐Chor; Yeung, William S.B.; Ho, PC; Ng, Ernest H.Y.

doi:10.12809/hkmj154710

Cited by 5 publications

(4 citation statements)

References 28 publications

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“…Five (9.43%) studies used more than one SSR technique. Amongst the 53 papers (Ando et al, 2013;Arafa et al, 2018;Bakircioglu et al, 2011;Brandell et al, 1998;Cetinkaya et al, 2015;Chehrazi et al, 2017;Chen et al, 2019;Choi et al, 2013;Emre Bakircioglu et al, 2006;Ferhi et al, 2009;Franik et al, 2018;Garolla et al, 2018;Goncalves et al, 2017;Greco et al, 2013;Güneri et al, 2016;Hopps et al, 2003;Huang et al, 2020;Ishikawa et al, 2009;Iwatsuki et al, 2017;Kizilkan et al, 2019;Klami et al, 2018;Kleiman et al, 2016;Ko et al, 2016;Koga et al, 2007;Madgar et Okada et al, 2005;Ozer et al, 2018;Ozveri et al, 2015;Park et al, 2013;Pavan-Jukic et al, 2020;Plotton et al, 2015;Pozzi et al, 2020;Ramasamy et al, 2009;Reubinoff et al, 1998;Rohayem et al, 2015;Sabbaghian et al, 2018;Salvarci & Zamani, 2018;Schiff et al, 2005;Schwarzer et al, 2016;Selice et al, 2010;Seo et al, 2004;…”

Section: Search Results and Characteristics Of Studiesunclassified

“…Quality assessment of the included studies revealed the majority of studies (n = 37; 69.81%) to be of fair quality scoring a total of 6 stars, while the remaining 16 (30.19%) studies were considered of high quality (8 studies scoring 9 stars (Bakircioglu et al, 2011;Chehrazi et al, 2017;Choi et al, 2013;Ishikawa et al, 2009;Plotton et al, 2015;Tsujimura et al, 2004;Yamaguchi et al, 2020;Zhang et al, 2021) and 8 studies scoring 7 stars (Arafa et al, 2018;Chen et al, 2019;Huang et al, 2020;Iwatsuki et al, 2017;Klami et al, 2018;Kleiman et al, 2016;Ko et al, 2016;Takeda et al, 2017).…”

Section: Search Results and Characteristics Of Studiesmentioning

confidence: 99%

“…Finally, the SSR rate of patients with chromosomal translocations and inversions has been reported for few cases in the literature (Güneri et al, 2016;Ko et al, 2016;Mascarenhas et al, 2016;Pavan-Jukic et al, 2020;Salvarci & Zamani, 2018;Takeda et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

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A systemic review and meta‐analysis exploring the predictors of sperm retrieval in patients with non‐obstructive azoospermia and chromosomal abnormalities

et al. 2021

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To identify the most prevalent chromosomal abnormalities in patients with nonobstructive azoospermia (NOA), consolidate their surgical sperm retrieval (SSR) rates and determine the significant predictors of positive SSR in this patient population.A systematic review and meta-analysis were performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.Fifty-three studies including 2965 patients were identified through searching the PubMed database. Klinefelter Syndrome (KS) was the most prevalent chromosomal abnormality reported in 2239 cases (75.5%). Azoospermia factor c (AZFc) microdeletions were the second most common (18.6%), but men with these deletions had higher SSR rates than patients with KS (41.95% with AZFc vs. 38.63% with KS). When examining predictors of SSR in KS patients, younger age was a significant predictor of positive SSR in patients undergoing microsurgical testicular sperm extraction (micro-TESE). Higher testosterone was a favourable predictor in those undergoing micro-TESE and conventional TESE. Lower luteinizing hormone (LH) and follicular stimulating hormone (FSH) values were significantly associated with positive SSR with testicular sperm aspiration (TESA). No parameter predicted SSR rates in patients with AZFc microdeletions. Overall, genetic abnormalities have significant implications on SSR success in patients with NOA.

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Section: Search Results and Characteristics Of Studiesunclassified

Section: Search Results and Characteristics Of Studiesmentioning

confidence: 99%

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A systemic review and meta‐analysis exploring the predictors of sperm retrieval in patients with non‐obstructive azoospermia and chromosomal abnormalities

et al. 2021

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“… 3 , 4 In addition, male factor infertility has been associated with reduced life expectancy and heavy financial burden, potentially causing excessive strain within personal relationships of those who suffer from the condition. 5 – 7 …”

Section: Introductionmentioning

confidence: 99%

An examination of predictive markers for successful sperm extraction procedures: a linear model and systematic review

Major

Edwards

Simpson

et al. 2022

Asian Journal of Andrology

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The authors performed a comprehensive review of current literature to create a model comparing commonly evaluated variables in male factor infertility, for example, follicle-stimulating hormone (FSH), testicular volume (TV), and testosterone (T), to better predict sperm retrieval rate (SRR). Twenty-nine studies were included, 9 with data on conventional testicular sperm extraction (cTESE) for a total of 1227 patients and 20 studies including data on microdissection testicular sperm extraction (mTESE) for a total of 4760 patients. A weighted-means value of SRR, FSH, T, and TV was created, and a weighted linear regression was then used to describe associations among SRR, type of procedure, FSH, T, and TV. In this study, weighted-means values demonstrated mTESE to be superior to cTESE with an SRR of 51.9% vs 40.1%. Multiple weighted linear regressions were created to describe associations among SRR, procedure type, FSH, T, and TV. The models showed that for every 1.19 mIU ml −1 increase in FSH, there would be a significant decrease in SRR by 1.0%. Seeking to create a more clinically relevant model, FSH values were then divided into normal, moderate elevation, and significant elevation categories (FSH <10 mIU ml −1 , 10–19 mIU ml −1 , and >20 mIU ml −1 , respectively). For an index patient undergoing cTESE, the retrieval rates would be 57.1%, 44.3%, and 31.2% for values normal, moderately elevated, and significantly elevated, respectively. In conclusion, in a large meta-analysis, mTESE was shown to be more successful than cTESE for sperm retrievals. FSH has an inverse relationship to SRR in retrieval techniques and can alone be predictive of cTESE SRR.

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The effects of Y chromosome microdeletions on in vitro fertilization outcomes, health abnormalities in offspring and recurrent pregnancy loss

Golin¹,

Yuen²,

Flannigan³

2021

Transl Androl Urol

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Male factor infertility accounts for approximately 50% of all infertility evaluations. A common cause of severe oligozoospermia and azoospermia is Y chromosome microdeletions (YCMs). Men with these genetic microdeletions must typically undergo assisted reproductive technology (ART) procedures to obtain paternity. In this review, we performed a thorough and extensive search of the literature to summarize the effects of YCMs on in vitro fertilization (IVF) outcomes, health abnormalities in offspring and recurrent pregnancy loss (RPL). The PubMed database was searched using specific search terms and papers were identified using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.Sperm retrieval amongst men with complete AZFa and/or AZFb deletions is extremely rare and thus data on ARTs is largely unavailable. In AZFc-deleted men undergoing assisted reproduction, the collective fertilization rate (FR) is 59.8%, the clinical pregnancy rate is 28.6% and the live birth rate is 23.4%.When successful, the YCM is always transmitted to the male offspring and the deletion size either remains unchanged or widens. YCMs generally result in decreased fertilization, clinical pregnancy and live birth rates compared to men with intact Y chromosomes during ART interventions. There is a minimal or absent association of YCMs with abnormalities in the offspring or RPL.

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Sperm retrieval rate and pregnancy rate in infertile couples undergoing in-vitro fertilisation and testicular sperm extraction for non-obstructive azoospermia in Hong Kong

Cited by 5 publications

References 28 publications

A systemic review and meta‐analysis exploring the predictors of sperm retrieval in patients with non‐obstructive azoospermia and chromosomal abnormalities

A systemic review and meta‐analysis exploring the predictors of sperm retrieval in patients with non‐obstructive azoospermia and chromosomal abnormalities

An examination of predictive markers for successful sperm extraction procedures: a linear model and systematic review

The effects of Y chromosome microdeletions on in vitro fertilization outcomes, health abnormalities in offspring and recurrent pregnancy loss

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