Sperm morphological abnormalities appearing in the male rabbit reproductive tract

The coiled tail of the round-headed spermatozoa appears during epididymal passage in GOPC-deficient mice

“…In wild mice, cytoplasmic droplet migration occurs when the spermatozoa pass through the middle caput epididymidis. This position is equivalent to that of other mammalian species such as moles (Suzuki and Racey, 1976), rabbits (Pérez-Sánchez et al,1997), and cats (Axnér et al, 1999).…”

“…Their configuration occurs during spermiogenesis through intricate cellular and molecular sequences. Furthermore, their final form is established during passage through the epididymis, where they undergo various functional and morphological modifications called "maturation changes" (for review; Yanagimachi, 1994) including the migration of the cytoplasmic droplet from the neck region to the distal end of the midpiece (Suzuki and Racey, 1976;Pérez-Sánchez et al,1997;Axnér et al, 1999).…”

Regulated upon activation normal T-cell expressed and secreted originating from the epididymis differentially associates with viable and defective spermatozoa

“…Based on the present findings, we postulated that RANTES may make the abnormal sperm more susceptible to spermiophage. Several studies documented the loss of visible defective spermatozoa during epididymal passage in normal, fertile animals (40)(41)(42). However, little is known about the mechanism behind the decrease in the proportions of the different sperm abnormalities observed in these studies.…”

Studies on the reproductive, cytological and biochemical toxicity of Ginkgo Biloba in Swiss albino mice

“…The discordance between these results might be related to the role of the excurrent duct system in eliminating morphologically abnormal spermatozoa during transit from testes to vas deferens and caudae epididymis. Previous studies (Perez-Sanchez et al, 1997;Chenoweth et al, 2000) have shown that the transit of spermatozoa through the extragonadal passage produces and/or eliminate morphologically abnormal spermatozoa by the excurrent duct system. The mechanism of these changes is yet a dilemma.…”