Sperm chromatin dispersion by formaldehyde in Wistar rats

Abstract

ABSTRACT. Formaldehyde (FA) is an environmental xenobiotic, which is genotoxic and carcinogenic to humans and animals; it induces DNA damage, mutations, and clastogenicity during critical cytogenetic events. FA-mediated oxidative stress is an important mechanism that has been associated with the induction of cytotoxic and genotoxic damage. Therefore, the objective of this study was to evaluate the dispersion of sperm chromatin and reproductive parameters induced by exposure to .0 ± 7.87, respectively; P = 0.0001). Histopathological alterations were evident, especially in the seminiferous tubules. In conclusion, this study provides experimental evidence concerning the genotoxicity of FA, with particular reference to the decreased sperm concentration and motility and increased dispersion of DNA chromatin in rats.

Semen Quality Following Long-term Occupational Exposure to Formaldehyde in China

“…The present findings, ie, long-term exposure to FA was associated with significant reductions in sperm motility, morphology, and DFI, were in agreement with animal studies . Significantly, nearly all the animal studies reported that FA exposure could decrease sperm number; however, similar declines were not observed in our study nor in the study by Wang et al The differences might result from different doses and time of exposure.…”

“…The present findings, ie, long-term exposure to FA was associated with significant reductions in sperm motility, morphology, and DFI, were in agreement with animal studies . Significantly, nearly all the animal studies reported that FA exposure could decrease sperm number; however, similar declines were not observed in our study nor in the study by Wang et al The differences might result from different doses and time of exposure. Animals were exposed to a relative high dose (10 mg/m 3 ) for a short period (<35 d), while humans were exposed to a relatively low dose (0.22-5.43 mg/m 3 ) for a longer period (>24 months).…”

Ginger ameliorates reproductive toxicity of formaldehyde in male mice: Evidences for Bcl-2 and Bax

“…The reduction of sperm quality in the present study indicates negative effects of oxidative stress induced by FA on male reproductive system. Several other studies have indicated the adverse effects of FA on sperm parameters (6,7,33,34) and our study is in line with them. FA has ability to cross the blood-testis barrier and induces oxidative stress by producing ROS which leads to degeneration of germ cells and disruption of spermatogenesis (6,33).…”

“…Henkel et al (36) demonstrated a direct correlation between sperm motility and decline in Leydig cells. A direct relationship between the FA exposure and dispersion of DNA chromatin of sperm was found by Betancourt-Martínez et al (34). In this research, Ginger extract improved sperm parameters when administrated simultaneously with FA.…”

Photobiomodulation Therapy Decreases Oxidative Stress in the Lung Tissue after Formaldehyde Exposure: Role of Oxidant/Antioxidant Enzymes

“…RONS are produced in high quantities by endogenous metabolisms which are represented primarily by the activation of neutrophils, the products of cyclooxygenase (COX), lipoxygenase (LOX), and nitric oxide synthases (NOS) [ 1 – 3 ]. At the same time, RONS are also produced in the body through exogenous factors including formaldehyde (FA), particulate matter (PM), metals, and quinones [ 4 – 9 ].…”