Sperm-Agglutinating Antibodies and Decreased Fertility in Prostitutes

Schwimmer, Walter B.; Ustay, K.; Behrman, S.J.

doi:10.1097/00006254-196802000-00026

Cited by 10 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Better understanding of the biochemistry of the acrosome might contribute to correc¬ tion of infertility or to the development of new approaches to conception control. Antibodies against spermatozoa have been suggested as the basis for certain cases of human infertility (Franklin & Dukes, 1964;Strauss, 1965;Schwimmer, Ustay & Behrman, 1967;Flällbrant, 1968;Hjort & Hansen, 1971;Otani, Ino, Inoue & Kagkami, 1971), and some evidence points to the acrosome as the major site of the antigens involved. A means of selectively removing the acrosome might provide the first step toward characterization of those antigens.…”

Section: Introductionmentioning

confidence: 99%

The Acrosome of the Human Spermatozoon: A New Method for Its Extraction, and an Analysis of Its Trypsin-Like Enzyme Activity

Pedersen¹

1972

Reproduction

View full text Add to dashboard Cite

A method is described for isolating the acrosomal material from human spermatozoa. Ejaculated spermatozoa are washed in a balanced salt solution containing glucose and dextran and are then rapidly frozen in liquid nitrogen, thawed at room temperature and the supernatant is collected after centrifugation. Electron microscope observations on the sperm pellet indicate a fairly selective removal of the acrosomal content with only minor damage to other parts of the spermatozoon. The presence of trypsin-like enzyme activity in the supernatant material thus obtained, was demonstrated by its ability to digest BAEE and TAME and by inhibition of this activity with soybean trypsin inhibitor and TLCK. Blood serum and seminal plasma were both found to contain a potent inhibitor of this enzyme activity. A reasonably consistent activity per mg of`acrosomal protein' makes it improbable that the enzymatic activity is found in an inhibited state in ejaculated spermatozoa.

show abstract

Section: Introductionmentioning

confidence: 99%

The Acrosome of the Human Spermatozoon: A New Method for Its Extraction, and an Analysis of Its Trypsin-Like Enzyme Activity

Pedersen¹

1972

Reproduction

View full text Add to dashboard Cite

show abstract

“…Bell & Wolf (1967) showed that the rabbit vagina is capable of producing antibodies in vitro after previous in vivo immuniza¬ tion. The localization of antibody to seminal antigens in the endometrium and cervical mucosa of human prostitutes has been reported by Schwimmer, Ustay & Behrman (1967).…”

mentioning

confidence: 99%

Early Embryo Mortality in Heifers Isoimmunized With Semen and Conceptus

Menge¹

1969

Reproduction

View full text Add to dashboard Cite

Isoimmunization of heifers by a single injection ofsemen and complete Freund's adjuvant up to 21 days after insemination resulted in a high incidence of early embryo loss. The heifers had a pregnancy rate of 11\m=.\8% and an incidence of delayed returns to oestrus of 41\m=.\3%.Only one of ten heifers immunized with semen had a fertilized ovum at slaughter after the second to fifth insemination. Pregnancy occurred in eight of ten control heifers immunized with seminal plasma after insemination. Heifers immunized with homologous conceptus material and adjuvant by repeated intra-uterine and intradermal injections required an average of 3\m=.\8inseminations per pregnancy. The infertility was apparently due to early embryo death. Isoimmunization with seminal plasma and immature testis, and the treatment of semen with antisera to conceptus and immature testis, had no effect on fertility in heifers.

show abstract

“…When the afferent limb is potentially overwhelmed with antigenic material, there is an increased incidence of antisperm antibodies. 90 There appears to be an adjuvant effect of microbiologic antigens on the formation of sperm antibodies, at least in the case of Schistosoma 91 and possibly Mycoplasma. 92 Some investigators have hypothesized that there are cross-reactive antigens between microorganisms and sperm that initiate an antibody response that results in the simultaneous formation of antisperm antibodies.…”

Section: Basic Immunologymentioning

confidence: 99%

The Uterine Cervix as an Immune Organ

Haas¹

1986

Semin Reprod Med

View full text Add to dashboard Cite

Sperm-Agglutinating Antibodies and Decreased Fertility in Prostitutes

Cited by 10 publications

References 0 publications

The Acrosome of the Human Spermatozoon: A New Method for Its Extraction, and an Analysis of Its Trypsin-Like Enzyme Activity

The Acrosome of the Human Spermatozoon: A New Method for Its Extraction, and an Analysis of Its Trypsin-Like Enzyme Activity

Early Embryo Mortality in Heifers Isoimmunized With Semen and Conceptus

The Uterine Cervix as an Immune Organ

Contact Info

Product

Resources

About