Spectrum of neuroimaging findings in COVID-19

Beltagi, Ahmed El; Vattoth, Surjith; Abdelhady, Mazen; Ahmed, Islam; Paksoy, Yahya; Kamar, Mohamed Abou; Alsoub, Hussam; Almaslamani, Muna; Al-Khal, Abdul Latif; Own, Ahmed; Elsotouhy, Ahmed

doi:10.1259/bjr.20200812

Cited by 13 publications

(28 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In adults, we observed a male predominance (73.68%, 14 cases) ( Abdi et al, 2020 ; Assunção et al, 2020 ; El Beltagi et al, 2021 ; Freire-Álvarez et al, 2020 ; Langley et al, 2020 ; Lopes et al, 2020 ; McCuddy et al, 2020 ; Paterson et al, 2020 ; Pilotto et al, 2021 ; Umapathi et al, 2020 ; Utukuri et al, 2020 ). The mean age was 49.8 years (25 to 70 years).…”

Section: Resultsmentioning

confidence: 67%

“…The comorbidity most frequently described was hypertension ( Lopes et al, 2020 ; McCuddy et al, 2020 ; Umapathi et al, 2020 ), followed by diabetes ( Lopes et al, 2020 ; McCuddy et al, 2020 ). Regarding the COVID-19 symptoms, 66.7% were severe ( N = 12/18)( Assunção et al, 2020 ; Langley et al, 2020 ; Lopes et al, 2020 ; McCuddy et al, 2020 ; Parsons et al, 2020 ; Paterson et al, 2020 ; Umapathi et al, 2020 ), 22.2% mild ( N = 4/18) ( El Beltagi et al, 2021 ; Freire-Álvarez et al, 2020 ; Kumar et al, 2020 ) and 11.1% asymptomatic ( N = 2/18)( Abdi et al, 2020 ; Utukuri et al, 2020 ). The COVID-19 diagnosis was made using a PCR test in 20 cases ( Abdi et al, 2020 ; Assunção et al, 2020 ; El Beltagi et al, 2021 ; Espíndola et al, 2021 ; Freire-Álvarez et al, 2020 ; Kumar et al, 2020 ; Langley et al, 2020 ; Lopes et al, 2020 ; McCuddy et al, 2020 ; Parsons et al, 2020 ; Paterson et al, 2020 ; Pilotto et al, 2021 ; Umapathi et al, 2020 ; Utukuri et al, 2020 ) and a serum antibody test (IgM and IgG antibody) in our case.…”

Section: Resultsmentioning

confidence: 99%

“…Including our original case report, we identified 30 patients (pediatric = 09, adults = 21) diagnosed with ADEM related with COVID-19 from 18 documents ( Abdel-Mannan et al, 2020 ; Abdi et al, 2020 ; Assunção et al, 2020 ; De Miranda Henriques-Souza et al, 2021 ; Dominguez- Rojas et al, El Beltagi et al, 2021 ; Espíndola et al, 2021 ; Freire-Álvarez et al, 2020 ; Kumar et al, 2020 ; Langley et al, 2020 ; Lindan et al, 2020 ; Lopes et al, 2020 ; McCuddy et al, 2020 ; Parsons et al, 2020 ; Paterson et al, 2020 ; Pilotto et al, 2021 ; 2020; Umapathi et al, 2020 ; Utukuri et al, 2020 ). Only one document was reported in non-English language (Spanish).…”

Section: Resultsmentioning

confidence: 99%

“…Thirteen cases (68.42%) had moderate/severe ADEM clinical presentation. The most frequent clinical characteristics were encephalopathy (84.2%, N = 16/19)( Abdi et al, 2020 ; Assunção et al, 2020 ; Espíndola et al, 2021 ; Freire-Álvarez et al, 2020 ; Kumar et al, 2020 ; Langley et al, 2020 ; Lopes et al, 2020 ; McCuddy et al, 2020 ; Parsons et al, 2020 ; Paterson et al, 2020 ; Pilotto et al, 2021 ; Umapathi et al, 2020 ; Utukuri et al, 2020 ), pyramidal signs (motor deficits such as hemiparesis or quadriparesis, hyperreflexia, or pathological reflexes such as Babinski) (63.1%, N = 12/19)( Abdi et al, 2020 ; El Beltagi et al, 2021 ; Langley et al, 2020 ; Lopes et al, 2020 ; McCuddy et al, 2020 ; Parsons et al, 2020 ; Paterson et al, 2020 ; Pilotto et al, 2021 ; Umapathi et al, 2020 ), brainstem involvement (15.7%, N = 3/19) ( Espíndola et al, 2021 ; Paterson et al, 2020 ), ataxia (15.7%, N = 3/19) ( El Beltagi et al, 2021 ; Utukuri et al, 2020 ), peripheral nerve involvement (confirmed by electromyography) (10.5%, N = 2/19) ( Kumar et al, 2020 ; Lopes et al, 2020 ) and seizures (5.3%, N = 1/19) ( Abdi et al, 2020 ). Most of the images found on the MRI, were hyperintensities in T2 and FLAIR.…”

Section: Resultsmentioning

confidence: 99%

“…Lesions in the subcortical white matter were multiple and less frequent in the periventricular area. Other frequent findings were brainstem lesions (45%, N = 9/20) ( Abdi et al, 2020 ; Assunção et al, 2020 ; El Beltagi et al, 2021 ; Kumar et al, 2020 ; McCuddy et al, 2020 ; Pilotto et al, 2021 ; Umapathi et al, 2020 ), hemorrhagic lesions (35%, N = 7/20) ( Langley et al, 2020 ; Lopes et al, 2020 ; Parsons et al, 2020 ; Paterson et al, 2020 ; Umapathi et al, 2020 ), spinal cord lesions (20%, N = 4/20) ( El Beltagi et al, 2021 ; Umapathi et al, 2020 ; Utukuri et al, 2020 ), deep gray matter compromise (25%, N = 5/20) ( Abdi et al, 2020 ; Freire-Álvarez et al, 2020 ; Lopes et al, 2020 ; Pilotto et al, 2021 ) and cerebellum involvement (15%, N = 3/20) ( Lopes et al, 2020 ; McCuddy et al, 2020 ; Umapathi et al, 2020 ). Likewise, 70% of cases had at least two affected territories, 100% had supratentorial involvement and 55% infratentorial involvement.…”

Section: Resultsmentioning

confidence: 99%

See 4 more Smart Citations

Acute disseminated encephalomyelitis and COVID-19: A systematic synthesis of worldwide cases

Zelada-Ríos

Pacheco‐Barrios

Galecio‐Castillo

et al. 2021

Journal of Neuroimmunology

View full text Add to dashboard Cite

Acute disseminated encephalomyelitis (ADEM) has been reported after coronavirus disease 2019 (COVID-19). In this review, we systematically included worldwide reported cases on this association. We included 30 case reports (pediatric and adults) and explored epidemiological and clinical evidence. We described time to diagnosis, clinical, imaging, and laboratory features, response to treatment regimens, and differences regarding severity. Also, an original case report was presented. Neurologists must be alert to the occurrence of multifocal neurological symptoms with or without encephalopathy in patients recovered from COVID-19. Timely MRI studies should be performed to establish the diagnosis and to consider early corticosteroid-based treatment.

show abstract

Section: Resultsmentioning

confidence: 67%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Acute disseminated encephalomyelitis and COVID-19: A systematic synthesis of worldwide cases

Zelada-Ríos

Pacheco‐Barrios

Galecio‐Castillo

et al. 2021

Journal of Neuroimmunology

View full text Add to dashboard Cite

show abstract

Diagnostic Approaches to Acute Neuro-COVID

Cascella

Blasio

2021

Features and Management of Acute and Chronic Neuro-Covid

View full text Add to dashboard Cite

Cerebrovascular Manifestations of SARS-CoV-2: A Comprehensive Review

Stefanou¹,

Karvelas

Bennett

et al. 2023

Curr Treat Options Neurol

View full text Add to dashboard Cite

Purpose of review The risks of cerebrovascular manifestations due to SARS-CoV-2 infection are significantly increased within the first 6 months of the infection. Our work aims to give an update on current clinical aspects of diagnosis and treatment of cerebrovascular manifestations during acute and long-term SARS-CoV-2 infection. Recent findings The incidence of acute ischemic stroke and haemorrhagic stroke during acute SARS-CoV-2 patients is estimated at 0.9 to 4.6% and 0.5–0.9%, respectively, and were associated with increased mortality. The majority presented with hemiparesis, dysarthria, sensory deficits, and a NIHSS score within 5–15. In addition, beyond the first 30 days of infection people with COVID-19 exhibited increased risk of stroke. During acute phase, age, hypertension, diabetes, and medical history of vascular disease were increased in patients with COVID-19 with new onset of cerebrovascular manifestations, while during long-COVID-19, the risk of cerebrovascular manifestations were found increased regardless of these factors. The management of patients with large-vessel ischemic stroke fulfilling the intravenous thrombolysis criteria are successfully treated according to the guidelines, while hyperosmolar therapy is typically administered in 4- to 6-h intervals. In addition, prophylaxis of anticoagulation therapy is associated with a better prognosis and low mortality during acute and post hospital discharge of patients with COVID-19. Summary In this work, we provide a comprehensive review of the current literature on acute and post-acute COVID-19 cerebrovascular sequelae, symptomatology, and its pathophysiology mechanisms. Moreover, we discuss therapeutic strategies for these patients during acute and long-term care and point populations at risk. Our findings suggest that older patients with risk factors such as hypertension, diabetes, and medical history of vascular disease are more likely to develop cerebrovascular complications.

show abstract

Spectrum of neuroimaging findings in COVID-19

Cited by 13 publications

References 41 publications

Acute disseminated encephalomyelitis and COVID-19: A systematic synthesis of worldwide cases

Acute disseminated encephalomyelitis and COVID-19: A systematic synthesis of worldwide cases

Diagnostic Approaches to Acute Neuro-COVID

Cerebrovascular Manifestations of SARS-CoV-2: A Comprehensive Review

Contact Info

Product

Resources

About