Spectrum of epilepsy in Wilson's disease with electroencephalographic, MR imaging and pathological correlates

Neurological manifestations in Wilson’s disease –possible treatment options for symptoms

“…[61] Other epidemiological study of epilepsy in 490 WD patients concluded that 8.3% (41/490) suffered epileptic seizures. [63] While generally confirming the earlier observations, [61] these authors described additional risk factors for epileptic seizures were described, including lesions of cortical white matter tracts (most frequently the frontal lobe, but also the parietal and occipital). Based on the available literature, partial seizures are typically observed, and the prognosis for recovery is diminished when they appear.…”

“…Based on the available literature, partial seizures are typically observed, and the prognosis for recovery is diminished when they appear. [63,64] The authors suggest that this phenomenon could occur during the natural course of WD, or result from WD 'overtreatment,' incurring copper deficiency. [64,65] Finally, when selecting antiepileptic drugs for WD patients (general rules for epilepsy treatment, not specific for WD), we should take into account their metabolism (hepatic biotransformation), potential hepatotoxicity together with the seizure type.…”

“…[64,65] Finally, when selecting antiepileptic drugs for WD patients (general rules for epilepsy treatment, not specific for WD), we should take into account their metabolism (hepatic biotransformation), potential hepatotoxicity together with the seizure type. [1][2][3][61][62][63][64][65][66] …”

Epileptic status immediately after initiation of d-penicillamine therapy in a patient with Wilson's disease

“…Generalized tonic-clonic, simple partial and complex partial epileptic seizures have been described before in Wilson's disease. Epileptic status is very rare and has been described in patients receiving treatment for several months or years [2]. However, this is to our knowledge the first report of an epileptic status immediately following initiation of d-penicillamine therapy.…”

“…As rapid decoppering therapy might result in neurological deterioration, careful dose titration is recommended [1]. Epileptic seizures have been described as a complication of long-term treatment, but not during early stages of decoppering therapy [2].…”