Spectroscopic studies of the molecular imprinting self-assembly process

Abstract

A method for the rapid estimation of the extent of complex formation in molecular imprinting prepolymerization mixtures is described. By the use of a UV spectroscopy titration procedure, apparent binding constants for such self-assembly processes have been obtained. This method was used for comparison of the interactions between a dipeptide template (N-acetyl-L-phenylalaninyl-L-tryptophanyl methyl ester) and the functional monomer methacrylic acid, and the monomer analogues acetic acid and trifluoroacetic acid. The importance of template-monomer association during the molecular imprinting prepolymerization phase is discussed with respect to the systems studied.

Detection of Acidic Pharmaceutical Compounds Using Virus-Based Molecularly Imprinted Polymers

“…However, these systems can be applied in the water purification field, because our results show that MIPs are selective and reusable. Furthermore, previous research showed that MIPs were stable over wide ranges of temperature, pH, and humidity [54]. The interaction of CA with the MIP-phage biocomposite further confirmed that CA has a higher affinity for MIP-phage than for MIP and NIP composites.…”

Synthetic Mechanism of Molecular Imprinting at the Solid Phase

“…This hypothesis stipulates that a successful imprinting depends on the association constant K a between the functional monomer and the template to assure the survival of the complex during polymerization. A number of spectroscopic and molecular modeling studies support this correlation. , …”

Multidimensional on-line sample preparation of verapamil and its metabolites by a molecularly imprinted polymer coupled to liquid chromatography–mass spectrometry

“…Several spectroscopic techniques, such as NMR [25,26], IR [27] or UV [28,29] have been developed to quantify this interaction. The interaction between verapamil and methacrylic acid was evaluated by a UV spectroscopic approach, as previously outlined by Mullett et al [28].…”