Spectroscopic optical coherence tomography for ex vivo brain tumor analysis

Lenz, Marcel; Krug, Robin; Dillmann, Christopher; Gerling, Alexandra; Gerhardt, Nils C.; Welp, Hubert; Schmieder, Kirsten; Hofmann, Martin R.

doi:10.1117/12.2252141

Cited by 1 publication

(2 citation statements)

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“…They set the attenuation threshold of 5.5 mm −1 determined by sensitivity and specificity test, and used it on murine brain cancer model, the result fitted well [20], [21]. Except for conventional intensity-based OCT, functional OCT has also been utilized for classification of normal brain tissues and tumorous tissues, such as spectroscopic OCT (S-OCT), which used the different portion of wavelengths of light reflecting back from samples and combined with machine learning, providing nice accuracy between tumorous and normal tissues [22]. In this study, we extent the use of functional OCT by providing the contrast between glioma and white matter and illustrating that glioma is undistinguishable from grey matter.…”

Section: Discussionmentioning

confidence: 87%

“…OCT is a promising imaging modality that have potential to be applied intraoperatively as brain surgery guidance system based on its unique properties. Several groups revealed the potential in differentiating brain tumors from normal brain tissues such as using intensity-based OCT only or with additional analysis like calculation of attenuation coefficient [18]- [21] and using spectroscopic OCT (S-OCT) combined with machine learning [22]. Furthermore, PS-OCT is one of the branches of OCT system that can provide extra intrinsic tissue information, including birefringence, optic axis orientation, and degree of polarization uniformity.…”

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confidence: 99%

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Polarization-Sensitive Optical Coherence Tomography for Brain Tumor Characterization

Chiu

Liu

et al. 2019

IEEE J. Select. Topics Quantum Electron.

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Complete removal of brain tumor is of the most interest to a surgeon because the resection area directly relates to recurrence rate. Although there are many biomedical imaging modalities applied to locate the positions of tumors, they lack the spatial resolution to precisely delineate the boundary between brain tumor and normal brain tissues and are also inconvenient to be used intraoperatively. This study aims to examine the feasibility of the label-free, polarization-sensitive optical coherence tomography (PS-OCT) for distinguishing brain tumors from normal brain tissues. Ex vivo samples were obtained from two patients with grade II and II-III glioma; healthy porcine brain tissues were utilized as the control group. In the results obtained from normal porcine brain, white matter contains significantly higher birefringent property over grey matter indicated by phase retardation. Based on the knowledge obtained from porcine brain experiment, a similar high-birefringent tissue is observed partially on the edge of the sliced glioma, and such tissue is considered as white matter because glioma originates through the mutation of the healthy white matter's glia cells. Additionally, differences between grey matter and brain tumor are not apparent based on phase retardation images and further histogram analysis. The capability of PS-OCT for distinguishing glioma from white matter is demonstrated. It could be a potential system to facilitate safe and maximum resection area, and finally, lead to ameliorated outcomes. Index Terms-Brain tumor, optical coherence tomography, optical polarization, white matter. I. INTRODUCTIONB RAIN tumor is a highly invasive tissue mutated from the normal cell, can be divided into benign and malignant tumor, depending on the growing speed and invasion level. Among various types of brain tumor, glioma is the most frequent pri-

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Section: Discussionmentioning

confidence: 87%

mentioning

confidence: 99%