2003
DOI: 10.1021/ac0207980
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Abstract: A novel application of near-infrared (near-IR) spectroscopy for the on-line determination of nanoparticle size of a drug compound in a high solids dispersion is described. The on-line spectroscopic technique provides real-time data for process monitoring and control and overcomes the limitations that are encountered using laboratory-based instrumentation for nanoparticle size determination. Near-IR spectroscopy is capable of providing an accuracy of 2.4 nm near the endpoint of particle production, where the vo… Show more

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Cited by 66 publications
(44 citation statements)
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“…[1][2][3] On-line analyses hold the promise of reducing or eliminating reworked batches, increasing manufacturing efficiency, decreasing the burden of finished product testing, and ensuring product quality throughout the manufacturing process. A substantial amount of time can be saved, and sampling difficulties minimized, by following reactions and processes in-situ composed for collecting samples and analyzing them in the laboratory with conventional approaches.…”
Section: Introductionmentioning
confidence: 99%
“…[1][2][3] On-line analyses hold the promise of reducing or eliminating reworked batches, increasing manufacturing efficiency, decreasing the burden of finished product testing, and ensuring product quality throughout the manufacturing process. A substantial amount of time can be saved, and sampling difficulties minimized, by following reactions and processes in-situ composed for collecting samples and analyzing them in the laboratory with conventional approaches.…”
Section: Introductionmentioning
confidence: 99%
“…The high concentration of solids within the colloidal dispersion investigated would have required sample dilution if the aforementioned off -line techniques were utilized; thus the on -line method eliminated this sample preparation need. 51 …”
Section: Nanomillingmentioning
confidence: 99%
“…8 Chemometric methods have been applied to NIR spectroscopic data by the pharmaceutical industry to determine drug contents, 9 polymorphic content, 10 and particle sizes of powders. 11,12 The key challenge in NIRS is to develop methods that not only are accurate enough to determine analytical parameters, such as content uniformity between different tablets, but also have an inherent robustness such that the prediction of concentration is insensitive to variations in, e.g., raw material particle size and batch quality. 13 The inherent high correlation of spectral shapes and thus difficulty and inability to distinguish the contributions from such parameters in NIRS spectra 14,15 require the development and maintenance of extensive calibration databases.…”
Section: Introductionmentioning
confidence: 99%