Spectroscopic and docking studies on the interaction between pyrrolidinium based ionic liquid and bovine serum albumin

Amino acid-based cationic gemini surfactant–protein interactions

“…The K a values obtained for BSA-(C 12 Cys) 2 complexes suggest lower binding affinity compared to other strong protein-ligand complexes with binding constants ranging from 10 5 to 10 8 L mol −1 [71,72] However, lower binding constants (10 2 -10 4 L mol −1 ) have been reported for several other protein-ligand complexes [26,27,50,[65][66][67]70,73]. In fact, the binding constants for imidazolium ionic liquids (ILs) and BSA are very low (in the order of 10 2 L mol −1 ) which indicate a very weak interaction between the ILs and the protein [58].…”

“…In fact, the binding constants for imidazolium ionic liquids (ILs) and BSA are very low (in the order of 10 2 L mol −1 ) which indicate a very weak interaction between the ILs and the protein [58]. This situation clearly contrasts with the pyrrolidinium-based IL synthesized by Kumari et al [72] which showed K SV and K a values of 3.45 × 10 5 and 3.33 × 10 5 L mol −1 , respectively, in phosphate buffer (pH 7.4) at 298 K. Khan et al [65,70] studied the binding of amphiphilic drugs amitriptyline hydrochloride (AMT), promethazine hydrochloride (PMT), nortriptyline hydrochloride (NOT) and promazine hydrochloride (PMZ) with serum albumins HSA and BSA. Fluorescence quenching data for the drug-protein complexes yielded values of K SV = (2.51-5.28) × 10 4 L mol −1 , K a = (0.46-32.5) × 10 4 L mol −1 and G b values between −21.00 and −31.60 kJ mol −1 in Tris-HCl buffer solution (pH 7.4) at 310 K [65,70].…”

In vitro Analysis of the Interaction between Human Serum Albumin and Semi‑Synthetic Clerodanes

“…[29][30][31][32] It is worth to note that results from the literature indicate that t-DCTN shows a much weaker binding ability for serum albumin than MHDCTN and PHDCTN. 13 Since the evaluation of the binding parameters between serum albumin and potential drugs is important to understand its distribution in the human plasma to body tissues and organs, the obtained binding ability between HSA:MHDCTN and HSA:PHDCTN suggests a decrease in the concentration of free molecules in the human plasma.…”

Surfactant–Amino Acid and Surfactant–Surfactant Interactions in Aqueous Medium: a Review

“…As the quantification of binding properties of ions, surfactants, biopolymers and other macromolecules, their structure and energetics of the self-assembly to nanometre-scale surfaces are often difficult experimentally and a recurring challenge in molecular simulations [183][184][185].Computational tools have been used to design and to screen amphiphilic surfactants to stabilize proteins and amphiphilic-amphiphilic systems for their better performance in industrial applications. Computational methods cut the time for screening the suitable and efficient amphiphilic surfactant systems to stabilize the protein [186,187]. A 3D Lattice Monte Carlo simulation method was used to investigate the micellization of pure gemini surfactants and a mixture of gemini and conventional surfactants.…”