Spectrophotometric method development and validation of itopride hydrochloride in bulk and dosage form.

Abstract

A simple, precise and economical spectrophotometric method for the estimation of Itopride hydrochloride in pharmaceutical bulk and tablet dosage form was developed and validated. Identification was carried out using a UVvisible double beam spectrophotometer detector with working wavelength at 258nm in 0.1N HCl medium. The method was validated with respect to its specificity, linearity range, accuracy, and precision in analytical media. Itopride hydrochloride show the maximum absorbance (λmax) at 258 nm, Regression analysis showed good correlation in the concentration range 5-100 mcg/ml and 96.80 to 106.84% recovery with relative standard deviation 0.293 to 3.98%. Statistical treatment of data reflects that the proposed method is precise, accurate and easily applicable for determination of Itopride hydrochloride in bulk and pharmaceutical preparation.

A study of selective spectrophotometric methods for simultaneous determination of Itopride hydrochloride and Rabeprazole sodium binary mixture: Resolving sever overlapping spectra

“…Quite a lot of analytical methods were reported for the determination of Itopride hydrochloride in its pure form, pharmaceutical preparations and human plasma, including spectrophotometric methods [3][4][5], electrochemical method [6], TLC [7], liquid chromatography with ultraviolet detection [8][9][10][11][12], chemiluminescence detection [13] and fluorescence detection [14][15][16]. On the other hand, RB was analyzed by applying several methods like; spectrophotometric methods [17][18][19][20][21][22], chemometric method [23] and spectroflourimetric methods [24,25].…”

Simultaneous determination of a binary mixture of pantoprazole sodium and itopride hydrochloride by four spectrophotometric methods

“…Several analytical methods have been developed for the determination of PAN in pharmaceutical preparations such as spectrophotometric methods [3][4][5][6], HPLC methods [7][8][9][10], HPTLC-densitometric methods [11,12] and liquid chromatographic-tandem mass methods (LC-MS/MS) [13,14]. Also several methods have been reported for the determination of ITH in pharmaceutical preparations such as spectrophotometric methods [15][16][17], HPLC methods [18][19][20], HPTLC-densitometric methods [21,22] and spectroflourimetric methods [23]. Simultaneous determination of PAN and ITH has been achieved by different spectrophotometric methods [24][25][26], HPLC methods [27,28], HPTLCdensitometric methods [29], spectroflourimetric methods [23].…”

Fourth‐derivative synchronous spectrofluorimetry and HPLC with fluorescence detection as two analytical techniques for the simultaneous determination of itopride and domperidone

“…The literature survey revealed that ITP has been determined by spectrophotometry , spectrofluorimetry , high‐performance thin‐layer chromatography (HPTLC) and several HPLC methods using UV , fluorescence , chemiluminescence and MS detection . Several methods have been reported for the determination of DOM including potentiometry , anodic differential pulse voltammetry , HPLC‐MS and HPLC with fluorescence detection .…”