Spectral, theoretical, physicochemical and corrosion inhibition studies of ortho-, meta- and para-hydroxyphenyl-benzoylthiourea ligands

Exploring the latest trends in chemistry, structure, coordination, and diverse applications of 1-acyl-3-substituted thioureas: a comprehensive review

“…46 To synthesize further derivatives of naphthoquinone-linked iminothiazoline, the naphthoquinone-based acyl thioureas were reacted with differently substituted a-bromoketones. Compounds synthesized were then characterized using various spectroscopic techniques by Efeoglu et al 47 N-Naphthoyl acyl thiourea derivatives were synthesized by Arafa et al and one of the synthesized derivatives N-(cyclohexylcarbamothioyl)-2-naphthamide (15) was subjected to different heterocyclization reactions. First, on reaction with chloroacetic acid in the presence of triethylamine produced thiazolidine analog (16), which via Knoevenagel condensation with 4-Cl-benzaldehyde furnished arylidene thiazolidine scaffold (17).…”

“…Second, via cyclization with a-bromoacetophenone in the presence of trimethylamine under sonication give thiazole-2-imine (18). Third, thiazole derivatives (19a-b) of the acyl thiourea were synthesized by dropwise addition of dialkyl acetylenedicarboxylates to a stirred solution of acyl thiourea (15) in ethanol at room temperature. Cyclization of acyl thiourea derivative with hydrazine hydrate in DCM as solvent under reux conditions furnished 1,2,4-triazole (20) and nally, tetrazole derivative (21) was synthesized by reacting thiourea and sodium azide under basic conditions using CuSO 4 $5H 2 O (50.0 mol%) as a catalyst (Scheme 5).…”

“…N-substituted-N-acyl thioureas appear as key building blocks for generating various heterocyclic products through cyclization, 8,9 as well as serving as precursors for anion receptors, 10,11 organocatalysts, [12][13][14] corrosion inhibitors 15 and nonionic surfactants. 16 Comprehensive research has documented the wide range of pharmacological benets associated with acyl thiourea derivatives, including their potential as anticonvulsant, 17 anticancer, [18][19][20] antidiabetic, 21 anti-inammatory, 22,23 anti-HIV, 24 antimicrobial, 25,26 urease inhibitory, 27 herbicidal, 28 and insecticidal agents.…”