Speckled Lentiginous Nevus (Nevus Spilus): The "Roots" of the "Melanocytic Garden"

Cramer, Stewart F.

doi:10.1001/archderm.137.12.1654

Cited by 24 publications

(23 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Particularly, loss of BAP-1 has been shown to cause loss of melanocyte identity in uveal melanoma and results in induction of stem cell properties. Moreover, uveal melanoma commonly exhibits a mutation in GNAQ [Cramer, 2001;Van Raamsdonk et al, 2009;Shoushtari and Carvajal, 2014]. Remarkably, the same mutation is also commonly exhibited in nevus of Ota, which again points towards a common pathway in the development of cutaneous periocular and eye melanocytic neoplasia.…”

Section: Hypothesis Of Uveal Melanoblastic Distribution and Disseminamentioning

confidence: 83%

A Unifying Concept of Uveal Pigment Cell Distribution and Dissemination Based on an Animal Model: Insights into Ocular Melanogenesis

Schwab

Wackernagel²,

Grinninger³

et al. 2016

Cells Tissues Organs

View full text Add to dashboard Cite

Pigmented cells are derived from neural crest cells, which migrate along the peripheral nerve sheets into their specific final region. During their migration, cells progressively acquire pigment-producing capabilities, maturation, and the shape of melanocytes. These insights, along with specific clinical characteristics of melanocytic nevi, have led to new concepts of cutaneous, periocular, and iris nevogenesis. To further elucidate the specific ocular embryogenic melanoblast distribution and dissemination - that could explain the distinct distribution of uveal melanocytic neoplasms - we investigated the ocular pigmentation of dogs affected by a specific mutation called Merle, which results in either pigment- (wild type) or non-pigment- (mutated type) producing cells. Based on our observations, we propose a unifying concept of uveal pigment cell distribution and dissemination, which postulates melanoblast migration and maturation following the trigeminal V1 branch and, later, their entrance into the eye along the ciliary nerves and their finest iris branches. Our concept provides an explanation not only for the specific distribution of ocular melanocytic lesions, including uveal and iris nevi, but also for the different locations depending on the metastatic potential of the ocular melanoma. Though speculative, the higher metastatic potential of posterior uveal melanomas compared to iris melanomas may be related to a less differentiated stage in the maturation of migrating melanocytes in the posterior segment compared to the anterior segment of the eye. However, there is a need of further studies focusing on cell differentiation markers of melanocytes at different locations in the eye.

show abstract

Section: Hypothesis Of Uveal Melanoblastic Distribution and Disseminamentioning

confidence: 83%

A Unifying Concept of Uveal Pigment Cell Distribution and Dissemination Based on an Animal Model: Insights into Ocular Melanogenesis

Schwab

Wackernagel²,

Grinninger³

et al. 2016

Cells Tissues Organs

View full text Add to dashboard Cite

show abstract

“…Otherwise, the area can be followed, and dermatoscopy with image storage can be helpful in the management of these lesions. [63][64][65][66] Shaffer and colleagues recommended self skin examination looking for focal changes in the NS as a means of finding an early melanoma. 17 If a melanoma arises in an NS, its management and prognosis are similar to those for any other melanomas.…”

Section: Discussionmentioning

confidence: 99%

Nevus Spilus and Melanoma: Case Report and Review of the Literature

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Additionally, from a pathogenetic point of view, any combined, agminated or systematized growth or the presence of terminal hair follicles should be regarded as indicative of a congenital lesion [1,4]. However, the true time of onset of a given melanocytic nevus may precede its visual perception on the skin surface by months or years and might be accelerated by UV-irradiation or hormonal influences, thus simulating a putatively acquired lesion [5–9]. …”

Section: Which Are the Features Of Congenital Nevi?mentioning

confidence: 99%

Spitz and Reed nevi: acquired or congenital?

Bär¹

2012

Dermatol Pract Concept

View full text Add to dashboard Cite

Speckled Lentiginous Nevus (Nevus Spilus): The "Roots" of the "Melanocytic Garden"

Cited by 24 publications

References 3 publications

A Unifying Concept of Uveal Pigment Cell Distribution and Dissemination Based on an Animal Model: Insights into Ocular Melanogenesis

A Unifying Concept of Uveal Pigment Cell Distribution and Dissemination Based on an Animal Model: Insights into Ocular Melanogenesis

Nevus Spilus and Melanoma: Case Report and Review of the Literature

Spitz and Reed nevi: acquired or congenital?

Contact Info

Product

Resources

About