Speckled lentiginous nevus

Stewart, D. M.

doi:10.1001/archderm.114.6.895

Cited by 26 publications

(8 citation statements)

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“…Macular SLN may occur as an isolated anomaly [3,4,5, 8, 17, 25] or as part of phacomatosis spilorosea(phacomatosis pigmentovascularis type III) (table 2) [18,19,20,21,22,23,24, 37]. We emphasize that the SLN associated with this complex birth defect is always of the macular type, regardless of the subclassification of various types of phacomatosis pigmentovascularis [18,19,20,21,22,23,24,25, 37].…”

Section: Macular Slnmentioning

confidence: 99%

“…Papular SLN may occur as an isolated lesion [1, 4, 5, 8, 13, 14, 43, 46, 49] or as a component of phacomatosis pigmentokeratotica [1,27,28,29,30,31,32, 50, 51,55,56,57]or of SLN syndrome (table 4) [33]. Phacomatosis pigmentokeratotica has been proposed to represent an example of didymosis (twin spotting) [26].…”

Section: Papular Slnmentioning

confidence: 99%

“…Matsudo et al [4] proposed the term zosteriform lentiginous nevus for such lesions. In 1978, Stewart et al [5] introduced the term speckled lentiginous nevus (SLN) to describe darkly pigmented speckles on a tannish-brown background, and they proposed to reserve the term nevus spilus to brown macules without speckles. These authors were successful in introducing SLN as a neologism, but unsuccessful in redefining the denomination nevus spilus.…”

Section: Introductionmentioning

confidence: 99%

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Two Distinct Types of Speckled Lentiginous Nevi Characterized by Macular versus Papular Speckles

Cruz

Happle²

2006

Dermatology

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Background: Speckled lentiginous nevus (SLN; synonym: nevus spilus) is a darkly spotted light-brown macule that mostly occurs as an isolated lesion of rather limited dimensions but sometimes may involve large areas of the body. So far, this skin disorder has been considered to represent one clinical entity. Objective: Because SLN is occasionally associated with complex birth defects such as phacomatosis pigmentovascularis, phacomatosis pigmentokeratotica, or SLN syndrome, we tested our idea that two different types of SLN may exist, each one associated with a particular syndrome. Methods: A review of case reports on SLN published during the years 1970–2004 was performed. Results: This evaluation of cases provided evidence that two different types of SLN exist, in the form of macular versus papular SLN, each one being related to a specific syndrome. Macular SLN is characterized by a tannish-brown background with darker flat speckles. The distribution of speckles is rather even and resembles a polka-dot pattern. Histopathologically, this type of SLN is characterized by what has been called a ‘jentigo’ pattern in the darker speckles and by some nests of melanocytes at the dermoepidermal junction at the tips of the papillae, whereas the background pigmentation shows the microscopical features of a lentigo. Papular SLN is characterized by a light-brown macule superimposed by multiple melanocytic nevi in the form of papules or nodules that show a more uneven distribution reminiscent of a star map. Small dark macules may likewise be present. Histopathologically, the papular component consists of dermal or compound melanocytic nevi. A separation of the two types of SLN is important because our analysis showed that macular SLN is a hallmark of a particular type of phacomatosis pigmentovascularis, whereas papular SLN is typically present in phacomatosis pigmentokeratotica as well as in SLN syndrome. Conclusions: Macular SLN and papular SLN appear to be two distinct cutaneous entities. This dichotomy may turn out to be important when such nevi will be analyzed at the molecular level.

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Section: Macular Slnmentioning

confidence: 99%

Section: Papular Slnmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Two Distinct Types of Speckled Lentiginous Nevi Characterized by Macular versus Papular Speckles

Cruz

Happle²

2006

Dermatology

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“…However, the patterns of admixture of the nevoid growths differ slightly between combined nevus and atypical blue nevus, and there are cases which belong to neither of the two groups. We herein report a case showing a combination of speckled lentiginous nevus (5) and patch-type blue nevus (6,7).…”

Section: Introductionmentioning

confidence: 97%

A Combination of Speckled Lentiginous Nevus with Patch‐type Blue Nevus

Misago

Narisawa

Kohda

1993

The Journal of Dermatology

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A peculiar case of "nevus on nevus" was reported. A 67-year-old man had had a pigmented lesion in the left hypochondrial area since birth. The clinicopathologic findings of the pigmented lesion revealed a combination of speckled lentiginous nevus and patch-type blue nevus. This case of "nevus on nevus" is not described under the term of combined nevus as is current in the literature; it was considered to be a subtype of the type II atypical blue nevus described by Kawamura.

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“…Dark brown pigmented macules and papules lying on a tan lentiginous patch is the characteristic finding. Histologically, the background area resembles lentigo simplex, whereas the darker spots usually show the features of a lentiginous nevus with lentigo-like areas progressing to junctional and even small compound nevi4. In contrast, agminated nevi usually occur during puberty and lack background pigmentation.…”

mentioning

confidence: 99%