Speckle reduction in quantitative phase imaging by generating spatially incoherent laser field at electroactive optical diffusers

Farrokhi, Hamid; Boonruangkan, Jeeranan; Chun, Byung Jae; Rohith, Thazhe Madam; Mishra, Awadhesh Kumar; Toh, Hui Ting; Yoon, Ho Sup; Kim, Young‐Jin

doi:10.1364/oe.25.010791

Cited by 29 publications

(18 citation statements)

References 23 publications

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“…It is because the coherent artifacts, such as speckle, diffraction, and intensity overshoot around the edges, degrade the image quality severely in both tradiational non-coherent imaging and coherenent quantitative phase imaging (QPI). In QPI, optical interference, enabled by the high degree of coherence of the lasers, superimposes unwanted background speckles so significantly hinders the successful phase reconstruction 1 – 6 . Thus, extensive research works on coherence control of light sources have been addressed 1 – 24 .…”

Section: Introductionmentioning

confidence: 99%

High-brightness laser imaging with tunable speckle reduction enabled by electroactive micro-optic diffusers

Farrokhi

Rohith

Boonruangkan

et al. 2017

Sci Rep

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High coherence of lasers is desirable in high-speed, high-resolution, and wide-field imaging. However, it also causes unavoidable background speckle noise thus degrades the image quality in traditional microscopy and more significantly in interferometric quantitative phase imaging (QPI). QPI utilizes optical interference for high-precision measurement of the optical properties where the speckle can severely distort the information. To overcome this, we demonstrated a light source system having a wide tunability in the spatial coherence over 43% by controlling the illumination angle, scatterer’s size, and the rotational speed of an electroactive-polymer rotational micro-optic diffuser. Spatially random phase modulation was implemented for the lower speckle imaging with over a 50% speckle reduction without a significant degradation in the temporal coherence. Our coherence control technique will provide a unique solution for a low-speckle, full-field, and coherent imaging in optically scattering media in the fields of healthcare sciences, material sciences and high-precision engineering.

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Section: Introductionmentioning

confidence: 99%

High-brightness laser imaging with tunable speckle reduction enabled by electroactive micro-optic diffusers

Farrokhi

Rohith

Boonruangkan

et al. 2017

Sci Rep

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“…Low spatial or temporal coherent source method [77][78][79][80][81][82][83][84][85][86][87][88][89][90] Recording one hologram Increasing the adjustment difficulty of light configuration OSH method [91][92][93][94] Higher signal-to-noise ratio Complicated setup and slower recording speed FINCH method [95][96][97][98] Higher signal-to-noise ratio and dynamic measurement…”

Section: Methods Advantage Limitationmentioning

confidence: 99%

“…Later in 2013, Lee et al [80] discussed the speckle noise reduction based on a synthetic Fourier transform light scattering. As a low spatial coherent source, Choi et al [81] in 2011 and Farrokhi et al [82] in 2017, employed the dynamic speckle illumination to suppress the speckle noise in DHM, respectively. At the same time, the low temporal coherent source was also applied as an illumination to reduce the source coherence.…”

Section: Coherent Noise Suppressionmentioning

confidence: 99%

Recent Progress on Aberration Compensation and Coherent Noise Suppression in Digital Holography

Liu

Wang

2018

Applied Sciences

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Digital holographic microscopy (DHM) is a topographic measurement technique that permits full-field, nondestructive, dynamic, quantitative amplitude, and phase-contrast imaging. The technique may realize the lateral resolution with submicron scale and the longitudinal resolution with subnanometer scale, respectively. Improving imaging quality has always been the research focus in DHM since it has a direct effect on the precise topographic measurement. In this paper, the recent progress on phase aberration compensation and coherent noise suppression is reviewed. Included in this review are the hologram spectrum's centering judgment methods of side band in tilt phase error compensation, the physical and numerical compensation methods in phase aberration compensation, and the single-shot digital process methods in coherent noise suppression. The summaries and analyses for these approaches can contribute to improving the imaging quality and reducing the measurement error of DHM, which will further promote the wider applications of DHM in the topographic measurement fields, such as biology and micro-electro mechanical systems.

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“…To remedy the coherent noise, numerous studies involving modifications of experimental setups or additional data capturing have been conducted [15][16][17][18][19][20]. Unfortunately, this class of methods works only when the imaging system has sufficient stability during measurement.…”

Section: Introductionmentioning

confidence: 99%

Cycle-consistent deep learning approach to coherent noise reduction in optical diffraction tomography

Choi¹,

Ryu

Jo³

et al. 2019

Opt. Express

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We present a deep neural network to reduce coherent noise in three-dimensional quantitative phase imaging. Inspired by the cycle generative adversarial network, the denoising network was trained to learn a transform between two image domains: clean and noisy refractive index tomograms. The unique feature of this network, distinct from previous machine learning approaches employed in the optical imaging problem, is that it uses unpaired images. The learned network quantitatively demonstrated its performance and generalization capability through denoising experiments of various samples. We concluded by applying our technique to reduce the temporally changing noise emerging from focal drift in time-lapse imaging of biological cells. This reduction cannot be performed using other optical methods for denoising.

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Speckle reduction in quantitative phase imaging by generating spatially incoherent laser field at electroactive optical diffusers

Cited by 29 publications

References 23 publications

High-brightness laser imaging with tunable speckle reduction enabled by electroactive micro-optic diffusers

High-brightness laser imaging with tunable speckle reduction enabled by electroactive micro-optic diffusers

Recent Progress on Aberration Compensation and Coherent Noise Suppression in Digital Holography

Cycle-consistent deep learning approach to coherent noise reduction in optical diffraction tomography

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