Speckle contrast optical tomography: A new method for deep tissue three-dimensional tomography of blood flow

Varma, Hari M.; Valdés, Claudia P.; Kristoffersen, Anna K.; Culver, Joseph P.; Durdurán, Turgut

doi:10.1364/boe.5.001275

Cited by 95 publications

(113 citation statements)

References 42 publications

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“…Speckle temporal dynamics gives information about intensity fluctuations connected with Brownian motion of biological molecules or flow of the blood particles. This is the basis for diffusion wave spectroscopy (DWS) or diffusion wave imaging (DWI) [5,52,53,61].…”

Section: Scattering Of the Coherent Light -Specklesmentioning

confidence: 99%

“…Scattering of light by movable particles is called dynamic light scattering in contrast to scattering of light by none movable or static particles, which is called static or elastic scattering as it occurs without energy transfer [5,9,[43][44][45][46][47][48][49][50][51][52][53][54][55][56]60]. Instead, at scattering by a movable particle small but measurable light energy change occurs, thus dynamic light scattering is often called as a quasi-elastic light scattering (QELS).…”

Section: Quasi-elastic Light Scattering (Qels) and Doppler Effectmentioning

confidence: 99%

“…The spatial distribution of contrast of a dynamic speckle pattern at its time-integration can be employed as a detecting parameter to provide a full-field velocity measuring technique [5,[46][47][48][49][50][51][52][53][54][55]. If the integration time is comparable with the period of the intensity fluctuations caused by dynamic light scattering, the effect of coherent light interaction with a RPS will be a blurring of the recorded speckle pattern -a reduction in the speckle contrast.…”

Section: Speckle Pattern Blurring Effect -Full-field Velocity Measurementioning

confidence: 99%

“…A fundamental difference of diffusion wave spectroscopy (DWS) compared to the QELS spectroscopy is that this approach is applicable in the case of dense media with multiple scattering, which is very important for tissues [5,52,53,61]. It is assumed thereby that due to multiple scattering the each photon that has reached given observation point of the detector experiences a great number of scattering events N (Fig.…”

Section: Diffusion Wave Spectroscopymentioning

confidence: 99%

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Tissue Optics and Photonics: Light-Tissue Interaction

Tuchin

2015

JBPE

138

152

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Abstract. This is the second section of the review-tutorial paper describing fundamentals of tissue optics and photonics. As the first section of the paper was mostly devoted to description of biological tissue structures and their specificity related to interactions with light [1], this section 3 describes light-tissue interactions themselves that are caused by tissue dispersion, scattering, and absorption properties, including light reflection and refraction, absorption, elastic, and quasi-elastic scattering. The major tissue absorbers and modes of elastic scattering, including Rayleigh and Mie scattering, will be presented. © 2015 Samara State Aerospace University (SSAU).

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Section: Scattering Of the Coherent Light -Specklesmentioning

confidence: 99%

Section: Quasi-elastic Light Scattering (Qels) and Doppler Effectmentioning

confidence: 99%

Section: Speckle Pattern Blurring Effect -Full-field Velocity Measurementioning

confidence: 99%

Section: Diffusion Wave Spectroscopymentioning

confidence: 99%

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Tissue Optics and Photonics: Light-Tissue Interaction

Tuchin

2015

JBPE

138

152

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“…In principle, this fact allows one to use position-dependent measurements of the temporal autocorrelation function of the field for tomographic reconstruction of the images of the dynamical inhomogeneities in the medium. This approach, referred to as diffuse optical correlation tomography in the literature [15,20,22,27,79,[219][220][221][222][223], has undoubtful prospects and is extensively developed now.…”

Section: Methods Based On the Detection Of Diffusely Scattered Lightmentioning

confidence: 99%

Diffuse optical mammotomography: state-of-the-art and prospects

Konovalov

Genina

Bashkatov

2016

JBPE

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Abstract:The principles of diffuse optical tomography (DOT) of tissues are presented. The DOT capabilities as a method of breast cancer diagnostics are analysed. The state-ofthe-art of the DOT instrumentation and methodological base in application to solving the mammography problems are described. The significant contribution of Russian scientists to the development of the DOT methodology is emphasised. Basing on the results of the analysis, the authors expect the possibility of soonest entry of diffuse optical mammotomographs to the market of medical imaging instrumentation, and the capability of Russian researchers to take part in the competition for this market. © 2016 Journal of Biomedical Photonics & Engineering.Key words: diffuse optical tomography, breast, optical and functional parameters, methods of determining optical parameters, methods of image reconstruction, perturbation model of reconstruction, temporal point spread function, spatial resolution, reconstruction time. University Press, Cambridge (2016). 7. S. R. Arridge, and M. Schweiger, "Inverse methods for optical tomography," in Information Processing in Medical Imaging, H.H. Barrett (ed.), Springer-Verlag, Flagstaff, 259-277 (1993). 8. J. C. Hebden, S. R. Arridge, and D. T. Delpy, "Optical imaging in medicine: I. Experimental techniques,"Phys. Med. Biol. 42, 825-840 (1997). 9. S. R. Arridge, and J. C. Hebden, "Optical imaging in medicine: II. Modelling and reconstruction," Phys. Med. Biol. 42, 841-853 (1997). 10. B. B. Das, F. Liu, and R. R. Alfano, "Time-resolved fluorescence and photon migration studies in biomedical and random media," Rep. Prog. Phys. 60, 227-292 (1997). 11. K. Michielsen, H. De'Raedt, J. Przeslawski, and N. Garcia, "Computer simulation of time-resolved optical imaging of objects hidden in turbid media," Phys. Rep. 304, 89-144 (1998). 12. S. R. Arridge, "Optical tomography in medical imaging," Inverse Problems 15, R41-R93 (1999). Darzi, "Diffuse optical imaging of the healthy and diseased breast: a systematic review," Breast Cancer Research and Treatment 108, 9-22 (2008). 19. S. L. Jacques, and B. W. Pogue, "Tutorial on diffuse light transport," J. Biomed. Opt. 13, 041302 (2008 Biol. 361, 171-179 (1994). 31. A. Yodh, and B. Chance, "Spectroscopy and imaging with diffusing light," Phys. Today 48, 34-40 (1995). 32. J. C. Hebden, S. R. Arridge, "Imaging through scattering media by the use of an analytical model of perturbation amplitudes in the time domain," Appl. Opt. 35, 6788-6796 (1996). 33. K. D. Paulsen, and H. Jiang, "Enhanced frequency-domain optical image reconstruction in tissues through total-variation minimization," Appl. Opt. 35, 3447-3458 (1996). 34. R. J. Grable, "Optical tomography improves mammography," Laser Focus World 32, 113-118 (1996). 35. V. V. Lyubimov, "The physical foundation of the strongly scattering media laser tomography," Proc. SPIE 2769SPIE , 107-110 (1996. 36. V. V. Lyubimov, "Optical tomography of highly scattering media by using the first transmitted photons of ultrashort pulses," Optics a...

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Assessing hyperthermia‐induced vasodilation in human skin in vivo using optoacoustic mesoscopy

Berezhnoi

Schwarz

Buehler

et al. 2018

Journal of Biophotonics

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The aim of this study was to explore the unique imaging abilities of optoacoustic mesoscopy to visualize skin structures and microvasculature with the view of establishing a robust approach for monitoring heat-induced hyperemia in human skin in vivo. Using raster-scan optoacoustic mesoscopy (RSOM), we investigated whether optoacoustic (photoacoustic) mesoscopy can identify changes in skin response to local heating at microvasculature resolution in a cross-sectional fashion through skin in the human forearm. We visualized the heat-induced hyperemia for the first time with single-vessel resolution throughout the whole skin depth. We quantified changes in total blood volume in the skin and their correlation with local heating. In response to local heating, total blood volume increased 1.83-and 1.76-fold, respectively, in the volar and dorsal aspects of forearm skin. We demonstrate RSOM imaging of the dilation of individual vessels in the skin microvasculature, consistent with hyperemic response to heating at the skin surface. Our results demonstrate great potential of RSOM for elucidating the morphology, functional state and reactivity of dermal microvasculature, with implications for diagnostics and disease monitoring. Image: Cross-sectional view of skin microvasculature dilated in response to hyperthermia. K E Y W O R D Shyperemia, induced hyperthermia, optoacoustic techniques, skin, vasodilation

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Speckle contrast optical tomography: A new method for deep tissue three-dimensional tomography of blood flow

Cited by 95 publications

References 42 publications

Tissue Optics and Photonics: Light-Tissue Interaction

Tissue Optics and Photonics: Light-Tissue Interaction

Diffuse optical mammotomography: state-of-the-art and prospects

Assessing hyperthermia‐induced vasodilation in human skin in vivo using optoacoustic mesoscopy

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