“…The heterogeneity in the clinical expression of Alzheimer's disease observed within the population of adults with Down syndrome may be due to the additive and/or interactive effects of a number of these risk factors, including, but not limited to genotypic variation, sex, age, health activity and diet [e.g., (Chace et al, 2007;Patel et al, 2004;Patel, Seltzer, Wu, & Schupf, 2001;Prasher et al, 2008 in press;Schupf, Kapell, Lee, Ottman, & Mayeux, 1994;Schupf et al, 1996;Schupf, Kapell et al, 2001;Schupf et al, 1998;Schupf et al, 2003;Schupf et al, 2007;Schupf et al, 2006;Zigman, Jenkins, Tycko, Schupf, & Silverman, 2005;]. The search for factors predictive of dementia in people with Down syndrome closely parallels analogous investigations in the typically developing population.…”