Specific tolerance without demonstrable chimerism: an alternative paradigm

Thomas, Judith M.; Lobashevsky, Andrew L.; Contreras, Juan L.; Eckhoff, Devin E.; Wang, Betsy; Hubbard, William J.; Thomas, F

doi:10.1097/00007890-199805131-00005

Cited by 1 publication

(1 citation statement)

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“…Notwithstanding, many investigators feel that chimerism is not necessary for development of tolerance. 72,73 Co-Stimulatory Blockade Briefly, antigens are processed by APCs and presented to host T-cells in context with the major histocompatibility complex (MHC), and this is considered signal one. More recently, CD28 was found to be a pivotal co-stimulatory molecule that provides a necessary "second signal" for the stimulation of T-cells when presented with antigen.…”

Section: H) Islet Purity and Viability Are Substantially Improved Wimentioning

confidence: 99%

Is Islet Transplantation a Realistic Therapy for the Treatment of Type 1 Diabetes in the Near Future?

Stevens¹,

Matsumoto²,

Marsh³

2001

Clinical Diabetes

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IN BRIEF Shapiro and colleagues recently reported a 100% cure rate for type 1 diabetes with their “Edmonton protocol” for islet transplantation. This unprecedented success has caused a groundswell of enthusiasm and an unparalleled effort to replicate their experience. It has also raised questions about the clinical reality of this therapy and sparked a dialog about which patients should benefit from receiving this scarce allocated resource. This article reviews the factors contributing to the Edmonton success and obstacles to immediate and long-term expansion of islet transplantation. The authors argue that use of the two-layered method of pancreas preservation will enable the Edmonton protocol to cure diabetes from single and marginal cadaveric donors. A concerted effort will be required to expedite routing of pancreases to islet processing centers and transplant programs. The long-term success and expansion of islet transplantation will depend on not only safer forms of immunosuppression, but also new sources of islet tissue.

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Section: H) Islet Purity and Viability Are Substantially Improved Wimentioning

confidence: 99%