Specific mucosal erosions in hypereosinophilic syndrome. Evidence for eosinophil protein deposition

In situ eosinophil activation in 26 primary cutaneous T-cell lymphomas with blood eosinophilia

“…44 IL-5 was expressed within both lymphoid cells and bilobate eosinophils in our cases; combined ultrastructural and immunohistochemistry studies have localized IL-5 to cytoplasmic granules of activated eosinophils. Activated eosinophils have been detected previously in blood 23 and tissue samples 27,39 from patients with hypereosinophilic syndrome, which can precede a clonal T-cell proliferation 40 in 25% to 50% of cases. 22,41 In primary CTCLs and T lymphomas following hypereosinophilic syndrome, atypical T lymphocytes produce Th2 cytokines, with release of IL-5, IL-3, and granulocyte-macrophage colony-stimulating factor.…”

“…7 Tissue eosinophil activation can be assessed from signs of degranulation observed with electron microscopy, extracellular release of constitutive eosinophil granule proteins such as eosinophil peroxidase (EPO), and in situ IL-5 neosynthesis by the eosinophil. [22][23][24] In this study of tissue eosinophils in CTCL patients with blood eosinophilia, we assessed tissue eosinophil density, signs of eosinophil activation, and their possible prognostic value.…”

Eosinophilic, Polymorphic, and Pruritic Eruption Associated With Radiotherapy

“…33 Eosinophilic major protein, cationic eosinophilic protein, and/or neurotoxin derived from eosinophils could also be involved in the pathogenesis of this condition as proposed for the idiopathic hypereosinophilic syndrome. 34,35 Tumor-associated tissue eosinophilia has been frequently described as a good prognostic sign in cervix carcinoma, [36][37][38] where tissue eosinophilia has been postulated to occur because of the formation or transformation of an antigen from the tumor due to radiotherapy, eliciting an immune dysregulation from the host. 32 Concerning blood eosinophilia, a higher TABE in patients with late stages (III and IV) of cervix carcinoma has been reported; a TABE increase in association with radiotherapy is frequent in early stages (I and II) of cervix carcinoma, and it has been claimed to represent a good pronostic sign (Ͼ50% regression).…”

Familial eosinophilia: a benign disorder?

“…Regardless of the etiology of the eosinophilia, however, the severity of the clinical pathology in HES is felt to reflect the extent of eosinophil activation in the tissues, and eosinophil granule proteins have been demonstrated in the serum and affected tissues of patients with HES. [5][6][7] We have previously described a 5-generation kindred with autosomal dominant transmission of marked eosinophilia (familial eosinophilia [FE]; Mendelian Inheritance in Man [MIM] 131400) in which progression to end organ damage (endomyocardial fibrosis and/or neuropathy) has occurred in a small subset (5 of 19) of affected family members. 8 Eosinophilia has been documented as early as 4 months of age and is remarkably stable over time in affected family members.…”