Specific Inhibition of Gastric Pepsin in the Treatment of Gastric Ulcer

Gastroprotective polysaccharide from natural sources: Review on structure, mechanism, and structure–activity relationship

“…Dietary supplement of Cladosiphon okamuranus fucoidan for 3 weeks could improve the ulcer healing of patients with severe GU (Juffrie et al., 2011). GU patients treated with a sulfated polysaccharide exhibited dominant decreases in ulcer size per day (Zimmon et al., 1969). Fucoidan administration could obviously increase mucus thickness of gastric mucosa in patients with chronic gastritis (Renaldi et al., 2011).…”

Double-blind randomised clinical trial of a pepsin-inhibitory pentapeptide (pepstatin) in the treatment of duodenal ulcer.

“…Most studies have focused on amylopectin sulphate (SN-263), which, however, seems to protect protein against the proteolytic activity of free pepsin rather than to precipitate the pepsin itself (Cammarata et al, 1971;Berstad, 1974;Kim et al, 1975). Amylopectin sulphate seems to accelerate gastric ulcer healing (Zimmon et al, 1969) and to promote a prophylactic effect on the recurrence rate of duodenal ulcer (Sun and Ryan, 1970). However, the drug has been reported to have neither a direct symptomatic effect in patients with radiologically demonstrated duodenal ulcer (Cocking, 1972;Baron, et al, 1977) nor an influence on the ulcer healing rate in patients with an active duodenal ulcer, when evaluated radiologically (Cocking, 1972) and endoscopically (Landecker et al, 1976).…”

Double-blind controlled trial of amylopectin sulphate (Depepsen) in the symptomatic treatment of duodenal ulcer.

“…Amylopectin sulphate (Depepsen, Searle) has been reported to be effective in both gastric and duodenal ulcer (Cayerand Ruffin, 1967;Zimmon, et al, 1969;Sun and Ryan, 1970), though a negative study has also appeared (Cocking, 1972). We report here a double-blind trial of this agent in the asymptomatic treatment of duodenal ulcer.…”