Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

1
21
0

Year Published

2009
2009
2022
2022

Publication Types

Select...
6

Relationship

0
6

Authors

Journals

citations
Cited by 20 publications
(22 citation statements)
references
References 14 publications
1
21
0
Order By: Relevance
“…On other hand, both basal levels and antigen-specific IgM were not altered in old mice (Speziali et al, 2009) suggesting that class-switch-independent IgM responses, being low affinity reactions, are less affected by repertoire limitations. Concerning the effects of ageing on the number of immunoglobulin-producing cells in the bone marrow, Speziali et al (2009) have shown that IgG, IgM and IgA immunoglobulin-producing cells were increased in aged mice and these results are coherent with the levels of serum immunoglobulins found, except for IgM that were unaltered in old mice. Frasca et al (2004Frasca et al ( , 2007, have shown that in vitro stimulated splenic B cells from senescent mice are deficient in the production of multiple class switch isotypes and that deficiency is correlated with decreased induction of transcription factor E47, poor activation-induced cytidine deaminase (AID) expression and consequent down-regulation of class switch recombination.…”
Section: B Lymphocytesmentioning
confidence: 88%
See 3 more Smart Citations
“…On other hand, both basal levels and antigen-specific IgM were not altered in old mice (Speziali et al, 2009) suggesting that class-switch-independent IgM responses, being low affinity reactions, are less affected by repertoire limitations. Concerning the effects of ageing on the number of immunoglobulin-producing cells in the bone marrow, Speziali et al (2009) have shown that IgG, IgM and IgA immunoglobulin-producing cells were increased in aged mice and these results are coherent with the levels of serum immunoglobulins found, except for IgM that were unaltered in old mice. Frasca et al (2004Frasca et al ( , 2007, have shown that in vitro stimulated splenic B cells from senescent mice are deficient in the production of multiple class switch isotypes and that deficiency is correlated with decreased induction of transcription factor E47, poor activation-induced cytidine deaminase (AID) expression and consequent down-regulation of class switch recombination.…”
Section: B Lymphocytesmentioning
confidence: 88%
“…Speziali et al (2009), have recently shown that basal levels of total serum immunoglobulins, IgG and IgA were increased while antigen-specific immunoglobulins, IgG and IgA were reduced in aged mice compared to young ones. This divergence between total and specific levels of Immunoglobulins, IgG and IgA may reflect the biased repertoire of B cells in aged mice (Koga et al, 2000) and their inability to mount specific immune responses to new antigens.…”
Section: B Lymphocytesmentioning
confidence: 99%
See 2 more Smart Citations
“…The immune system may play an important role in occurring various disease and the changes in the immune status are associated with treatment of various immune-modulators (Speziali et al, 2009). This study examined the immunemodulatory (stimulatory/inhibitory) effects of EBE supplementation on the functions of peritoneal macrophages in rats.…”
Section: Resultsmentioning
confidence: 99%