2015
DOI: 10.1038/nutd.2015.9
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Abstract: Background:Gut microbial gene richness and specific bacterial species are associated with metabolic risk markers in humans, but the impact of host physiology and dietary habits on the link between the gut microbiota and metabolic markers remain unclear. The objective of this study was to identify gut metagenomic markers associated with estimates of insulin resistance, lipid metabolism and inflammation in obesity, and to explore whether the associations between metagenomic and metabolic markers persisted after … Show more

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Cited by 209 publications
(141 citation statements)
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“…We demonstrated a decreased Akkermansia abundance in psoriasis patients (Table ), which was consistent with a prior study for new‐onset PsA . Akkermansia muciniphila is a notable example species of Verrucomicrobia whose abundance has been negatively correlated with obesity, insulin resistance and metabolic disorder, and positively with exercise and weight loss . The decreased Akkermansia spp .…”
Section: Discussionmentioning
confidence: 99%
“…We demonstrated a decreased Akkermansia abundance in psoriasis patients (Table ), which was consistent with a prior study for new‐onset PsA . Akkermansia muciniphila is a notable example species of Verrucomicrobia whose abundance has been negatively correlated with obesity, insulin resistance and metabolic disorder, and positively with exercise and weight loss . The decreased Akkermansia spp .…”
Section: Discussionmentioning
confidence: 99%
“…Stein () reported that the prevalence of Prevotella significantly reduced in mice with renal failure, which was in line with the findings of the present study. Holdemanella biformis was associated with an unhealthy fasting serum lipid profile (Brahe et al., ). Megamonas had a higher proportion in samples with obesity (Chiu et al., ).…”
Section: Discussionmentioning
confidence: 99%
“…And after limiting energy intake for 6 weeks, patients with a high abundance of A. muciniphila at baseline had significantly improved insulin sensitivity and other obesity-related clinical indicators. Akkermansia muciniphila can be therefore used as a metabolic marker to indicate the reduction in the risk of obesity (Brahe et al, 2015), and it might be directly used to improve the glucose and lipid metabolism to treat obesity. Recently, Chelakkot et al (2018) reported that compared to patients with type 2 diabetes, healthy human contained more A. muciniphila extracellular vesicles (AmEVs) in faeces.…”
Section: Metabolic Disorders and A Muciniphilamentioning
confidence: 99%