Specific Celiac Disease Antibodies in Children on a Gluten-Free Diet

Abstract

Doctors taking care of children with CD should be aware that the mean concentration of anti-TG2 will show a 74% decrease (95% confidence interval: 69%-79%) after 3 months of gluten-free diet, and ∼80% of the children will be sero-negative for EMA and anti-TG2 after 2 years of the diet.

Coeliac disease in the ERA of the new ESPGHAN and BSPGHAN guidelines: a prospective cohort study

“…The percentage of children with normal antibody values was comparable in the two groups at every year of follow-up, increasing from about 80% at 1 year to >95% at 3 years after diagnosis, as reported in other series 13. Despite the serum anti-tTG IgA antibody values not being absolutely sensitive in assessing the compliance with a GFD,14 they represent another parameter suggesting a similar adherence to diet in the two groups.…”

Dietitian visits were a safe and cost‐effective form of follow‐up care for children with celiac disease

“…A limitation of the study was that we only included a subset of patients in the surrounding areas of Malmö and Lund in southern Sweden for a rather short period of time. Although the majority of children showed normalised IgA‐tTG levels during the first 12 months after starting on a GFD , the samples were not checked in the same time frame and frequency for every patient. Therefore, we could not eliminate all potential biases for the IgA‐tTG analysis.…”

Prospective antibody case finding of coeliac disease in type‐1 diabetes children: need of biopsy revisited

“…TG2‐IgA and EMA tests may be used in the follow‐up of children with CD on a gluten‐free diet to monitor healing . This is also the case in asymptomatic CD patients with concomitant type 1 diabetes.…”