2017
DOI: 10.1101/220343
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Abstract: Mammals display wide range of variation in their lifespan. Lifespan is generally 29 correlated to body size, but outliers such as human and the naked mole-rat 30 (NMR, Heterocephalus glaber) exist. Investigating the molecular networks that 31 distinguish long-from short-lived species has proven useful to identify 32 determinants of longevity. Here, we compared the liver of long-lived NMRs and 33 the phylogenetically closely related, shorter-lived, guinea pigs (GP, Cavia 34 porcellus) using an integrated transc… Show more

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Cited by 9 publications
(10 citation statements)
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“…Inclusion criteria for a manuscript included healthy individuals, proteomics results published on or after 2010, publications/authors provided list of significant/all proteins. Thirty three manuscripts met the inclusion criteria, including 12 that covered human plasma (Enroth et al, 2015; Lehallier et al, 2019; Lind et al, 2019; Menni et al, 2015; Ngo et al, 2016; Orwoll et al, 2018; Santos‐Lozano et al, 2020; Sun et al, 2018; Tanaka et al, 2018; Wang, Zhu, et al, 2019; Wang, Zhang, et al, 2019; Ye et al, 2019), 9 from 14 different matrices in humans (Baird et al, 2012; Bakun et al, 2014; Bell‐Temin et al, 2019; Gueugneau et al, 2014; Heinze et al, 2018; Hennrich et al, 2018; Ubaida‐Mohien et al, 2019; Waldera‐Lupa et al, 2014; Wang, Wang, et al, 2018), and 12 publications covering 21 different species/matrices (Amin et al, 2020; Angelidis et al, 2019; Braun et al, 2016; Cutler et al, 2017; Drulis‐Fajdasz et al, 2018; Gebert et al, 2020; Heinze et al, 2018; Kelley et al, 2018; Meng et al, 2020; Stauch et al, 2015; Wang, Zhu, et al, 2019; Yu et al, 2020). The age range of participants included in these studies spanned from 14 to 103 years, and measures were carried out using multiple platforms including but not limited to liquid chromatography–mass spectrometry (LC‐MS)‐based proteomics, multiplexed proteomic assay using modified aptamers (SOMAscan) and Proximity Extension Assay (PEA, O‐Link) (Gold et al, 2010; Lundberg et al, 2011).…”
Section: Methodsmentioning
confidence: 99%
“…Inclusion criteria for a manuscript included healthy individuals, proteomics results published on or after 2010, publications/authors provided list of significant/all proteins. Thirty three manuscripts met the inclusion criteria, including 12 that covered human plasma (Enroth et al, 2015; Lehallier et al, 2019; Lind et al, 2019; Menni et al, 2015; Ngo et al, 2016; Orwoll et al, 2018; Santos‐Lozano et al, 2020; Sun et al, 2018; Tanaka et al, 2018; Wang, Zhu, et al, 2019; Wang, Zhang, et al, 2019; Ye et al, 2019), 9 from 14 different matrices in humans (Baird et al, 2012; Bakun et al, 2014; Bell‐Temin et al, 2019; Gueugneau et al, 2014; Heinze et al, 2018; Hennrich et al, 2018; Ubaida‐Mohien et al, 2019; Waldera‐Lupa et al, 2014; Wang, Wang, et al, 2018), and 12 publications covering 21 different species/matrices (Amin et al, 2020; Angelidis et al, 2019; Braun et al, 2016; Cutler et al, 2017; Drulis‐Fajdasz et al, 2018; Gebert et al, 2020; Heinze et al, 2018; Kelley et al, 2018; Meng et al, 2020; Stauch et al, 2015; Wang, Zhu, et al, 2019; Yu et al, 2020). The age range of participants included in these studies spanned from 14 to 103 years, and measures were carried out using multiple platforms including but not limited to liquid chromatography–mass spectrometry (LC‐MS)‐based proteomics, multiplexed proteomic assay using modified aptamers (SOMAscan) and Proximity Extension Assay (PEA, O‐Link) (Gold et al, 2010; Lundberg et al, 2011).…”
Section: Methodsmentioning
confidence: 99%
“…While many previous large-scale omics studies on aging focused on genome-wide association [6265], recent comparative studies on transcriptomics [66, 67], proteomics [6870], metabolomics [7173] and ionomics [72] have begun to shed light on molecular patterns and mechanisms that link to endophenotypes. For example, it has been suggested that natural variation is associated with extensive changes in gene expression, translation and metabolic regulation, which in turn may affect selection under different stress conditions [74, 75].…”
Section: Resultsmentioning
confidence: 99%
“…Homogenized quadriceps muscle samples were lysed in RIPA buffer followed by reduction, alkylation and subsequent acetone precipitation. Protein pellets were digested into peptides, labeled with 10plex Tandem Mass Tags (Thermo Fisher) and fractionated by high pH reverse phase chromatography, as described earlier (40). The resulting fractions were combined into 24 pools and analyzed in an Orbitrap Fusion Lumos Tribrid Mass Spectrometer (Thermo Fisher) using a synchronous precursor selection (SPS)/MS3 method (41).…”
Section: Mass Spectrometry Analysis Of Skeletal Muscle Proteinsmentioning
confidence: 99%