Specialised Coating Processes Finding Pharmaceutical Applicability

Abstract

The manuscript aims at furnishing comprehensive information pertaining specialised coating technology/ processes. Solid dosage forms and solid particulates (SDFSP) are the major contributing group in the solid pharmaceuticals (SoPs). SDFSP exhibit peculiar physico-chemical properties and interaction behaviour which create problems/ issues during their handling, processing, storage, and use. Modifying and/or engineering surface attributes of SDFSP are advocated as powerful tool to modify their interaction behaviour and realise their worthy applications and functionalities. In this regard coating their surfaces with coating material (CM) is novel approach. Said approach involves wet and dry process for realising deposition of CM onto the surface of SDFSP substrates. Both the processes modify and/or alter innate properties of SDFSP substrates either physically or chemically. Basing on involved wet or dry process the coating method is either dry coating method (DCM) or wet coating method (WCM). Accordingly nowadays there available number of specialised devices, that bases on diverse technologies. Amongst them some involves state-of-art process/ technology like Supercell coating technology (SCT), Chemical vapour deposition (CVD), Atomic/molecular layer deposition (AMLD), Electrostatic deposition, Thermo-mechanical process, Resonant acoustic technology, Fluidised-bed process, Supercritical fluid (SCF) technology, and others. These foundational for commercially availability of specialised equipments like Magnetically Assisted Impaction Coater (MAIC), Resodyn acoustic mixer, Hybridizer®, Theta-composer®. Mechanofusion®, and others. Working and working principle, applicability, benefits, pros and limitations of specialised coating processes and technologies are herein discussed and presented. Contained information hoped to be beneficent for pharmaceutical professionals and technocrats and professionals of allied field.
 Keywords: Coating, composite product, modification, specialised, surface.

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“…In the present scenario, available CoPr is of diverse types & origins [1][2][3]17 . Generalizing their basic principle in broader terms is a wispy attempt 4,5,17 .…”

“…exploited techniques/ process for modification in surface attributes/ properties of them aims to alter their innate properties physically or chemically and to receive assorted advantage 10,13,[16][17][18] . Amongst them, pharmaceutical applications frequently aim for protective (non-functional) and/or functional purposes [16][17][18] .…”

“…CoPr in present days has a diversity of type & origin; refer to Fig. 1 1,6,10,17 . The associates and inherits complex processing steps of diverse types and origins 1,6,13,16,17 .…”

“…1 1,6,10,17 . The associates and inherits complex processing steps of diverse types and origins 1,6,13,16,17 . Their generalization in wider terms is wispy task 6,13,17 .…”

“…However, in general, a principle is deposition that involves applying CoMa onto a moving substratebed (S-B) with the involvement of concurrent processing step facilitating fixing of CoMa on the S-S 4,6,7,[9][10][11]17 . The CoPr and equipment is must have proviso for 7, 9-11 :…”