Spatiotemporally Controlled Microchannels of Periodontal Mimic Scaffolds

Park, Chi Hyun; Kim, K.H.; Ríos, Héctor F.; Lee, Y.M.; Giannobile, William V.; Seol, Yang‐Jo

doi:10.1177/0022034514550716

Cited by 58 publications

(71 citation statements)

References 35 publications

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“…Nano-HA also resembles the biological apatite due to its ultrafine structure, hence playing a pivotal role in hard tissue replacement [52]. Furthermore, directional freezing process can be employed to assist PDL growth, by controlling the freezing orientation to fabricate sub longitudinal pores with angular similarities to native PDL [24].…”

Section: Discussionmentioning

confidence: 99%

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Freeze gelated porous membranes for periodontal tissue regeneration

et al. 2015

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Guided tissue regeneration (GTR) membranes have been used for the management of destructive forms of periodontal disease as a means of aiding regeneration of lost supporting tissues, including the alveolar bone, cementum, gingiva and periodontal ligaments (PDL). Currently available GTR membranes are either non-biodegradable, requiring a second surgery for removal, or biodegradable. The mechanical and biofunctional limitations of currently available membranes result in a limited and unpredictable treatment outcome in terms of periodontal tissue regeneration. In this study, porous membranes of chitosan (CH) were fabricated with or without hydroxyapatite (HA) using the simple technique of freeze gelation (FG) via two different solvents systems, acetic acid (ACa) or ascorbic acid (ASa). The aim was to prepare porous membranes to be used for GTR to improve periodontal regeneration. FG membranes were characterized for ultra-structural morphology, physiochemical properties, water uptake, degradation, mechanical properties, and biocompatibility with mature and progenitor osteogenic cells. Fourier transform infrared (FTIR) spectroscopy confirmed the presence of hydroxyapatite and its interaction with chitosan. μCT analysis showed membranes had 85-77% porosity. Mechanical properties and degradation rate were affected by solvent type and the presence of hydroxyapatite. Culture of human osteosarcoma cells (MG63) and human embryonic stem cell-derived mesenchymal progenitors (hES-MPs) showed that all membranes supported cell proliferation and long term matrix deposition was supported by HA incorporated membranes. These CH and HA composite membranes show their potential use for GTR applications in periodontal lesions and in addition FG membranes could be further tuned to achieve characteristics desirable of a GTR membrane for periodontal regeneration.

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Section: Discussionmentioning

confidence: 99%

“…The freezing process can be carried out in a more controlled manner to orient the growth of ice crystals in a particular direction [22,23]. More recently Park et al have used directional freeze-casting with gelatine to mimic topographies with angular similarities of the alveolar crest and natural orientation of periodontal ligaments [24].…”

Section: Introductionmentioning

confidence: 99%

Freeze gelated porous membranes for periodontal tissue regeneration

et al. 2015

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“…Using 3D printing and directional freeze‐casting techniques, a fiber‐guiding hybrid scaffold has been designed to spatiotemporally control the morphogenesis, integration, and functionalization of various tissues . Animal experiments have shown that this customized fiber‐guiding scaffold can accurately adapt to defect sites and thus successfully guide cell/tissue directionality during regeneration and facilitate the formation of a more stable ligament‐ligand complex with a rapidly maturing matrix .…”

Section: Periodontal Tissue Engineering Via In Vitro Cell‐materials Dementioning

confidence: 99%

“…More recently, a similar “3D‐patterned, periodontal mimic multiphasic architecture” approach was reported, taking his technology one step closer to clinical translation . The aforementioned fiber‐guiding scaffold has been approved by the U.S. Food and Drug Administration for clinical use . Collectively, 3D‐patterned multiphasic complexes have enabled the reconstruction of periodontal complex architectures for periodontal tissue engineering strategies, but when translated to clinical use, the complexity of tissue‐engineered constructs must be kept to a minimum to ensure cost‐effectiveness and ease of production.…”

Section: Periodontal Tissue Engineering Via In Vitro Cell‐materials Dementioning

confidence: 99%

Concise Review: Periodontal Tissue Regeneration Using Stem Cells: Strategies and Translational Considerations

Wang

et al. 2018

Stem Cells Translational Medicine

151

122

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Periodontitis is a widespread disease characterized by inflammation‐induced progressive damage to the tooth‐supporting structures until tooth loss occurs. The regeneration of lost/damaged support tissue in the periodontium, including the alveolar bone, periodontal ligament, and cementum, is an ambitious purpose of periodontal regenerative therapy and might effectively reduce periodontitis‐caused tooth loss. The use of stem cells for periodontal regeneration is a hot field in translational research and an emerging potential treatment for periodontitis. This concise review summarizes the regenerative approaches using either culture‐expanded or host‐mobilized stem cells that are currently being investigated in the laboratory and with preclinical models for periodontal tissue regeneration and highlights the most recent evidence supporting their translational potential toward a widespread use in the clinic for combating highly prevalent periodontal disease. We conclude that in addition to in vitro cell‐biomaterial design and transplantation, the engineering of biomaterial devices to encourage the innate regenerative capabilities of the periodontium warrants further investigation. In comparison to cell‐based therapies, the use of biomaterials is comparatively simple and sufficiently reliable to support high levels of endogenous tissue regeneration. Thus, endogenous regenerative technology is a more economical and effective as well as safer method for the treatment of clinical patients. Stem Cells Translational Medicine 2019;8:392–403

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“…( b ) Periodontal ligament (PDL), alveolar bone (AB), gingiva (G), inferior alveolar artery (IAA), Volkmann’s canals (VC) [22,23]. …”

Section: Introductionmentioning

confidence: 99%

Advanced Engineering Strategies for Periodontal Complex Regeneration

et al. 2016

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The regeneration and integration of multiple tissue types is critical for efforts to restore the function of musculoskeletal complex. In particular, the neogenesis of periodontal constructs for systematic tooth-supporting functions is a current challenge due to micron-scaled tissue compartmentalization, oblique/perpendicular orientations of fibrous connective tissues to the tooth root surface and the orchestration of multiple regenerated tissues. Although there have been various biological and biochemical achievements, periodontal tissue regeneration remains limited and unpredictable. The purpose of this paper is to discuss current advanced engineering approaches for periodontal complex formations; computer-designed, customized scaffolding architectures; cell sheet technology-based multi-phasic approaches; and patient-specific constructs using bioresorbable polymeric material and 3-D printing technology for clinical application. The review covers various advanced technologies for periodontal complex regeneration and state-of-the-art therapeutic avenues in periodontal tissue engineering.

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Spatiotemporally Controlled Microchannels of Periodontal Mimic Scaffolds

Cited by 58 publications

References 35 publications

Freeze gelated porous membranes for periodontal tissue regeneration

Freeze gelated porous membranes for periodontal tissue regeneration

Concise Review: Periodontal Tissue Regeneration Using Stem Cells: Strategies and Translational Considerations

Advanced Engineering Strategies for Periodontal Complex Regeneration

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