Spatiotemporal Dynamics of Error Processing Dysfunctions in Major Depressive Disorder

Holmes, Avram J.; Pizzagalli, Diego A.

doi:10.1001/archgenpsychiatry.2007.19

Cited by 251 publications

(273 citation statements)

References 78 publications

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“…Major depression is another condition that can affect the size of the ERN (Ruchsow et al, 2006;Chiu and Deldin, 2007;Holmes and Pizzagalli, 2008), although not always (Schrijvers et al, 2009;Bailey et al, 2015). We saw no relationship between ERN amplitude and the severity of depression symptoms reported on the BDI.…”

Section: Error-related Negativity and Depressionmentioning

confidence: 49%

“…Individuals with schizophrenia show reductions in the ERN (Alain et al, 2002;Mathalon et al, 2002), whereas those with generalized anxiety disorder (GAD) and OCD show increases (Gehring et al, 2000;Endrass and Ullsperger, 2014;Xiao et al, 2011). The findings in major depressive disorder are mixed, with some studies showing increases in ERN amplitude (Chiu and Deldin, 2007;Holmes and Pizzagalli, 2008;Aarts et al, 2013) and others decreases (Ruchsow et al, 2006) or no difference (Compton et al, 2008;Schrijvers et al, 2009). Co-morbid conditions that occur with depression may account for some of the mixed results.…”

Section: Introductionmentioning

confidence: 99%

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Intact error monitoring in combat Veterans with post-traumatic stress disorder

Swick

Honzel

Turken

2015

Psychiatry Research: Neuroimaging

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The error-related negativity (ERN) is a neuroelectric signature of performance monitoring during speeded response time tasks. Previous studies indicate that individuals with anxiety disorders show ERN enhancements that correlate with the degree of clinical symptomology. Less is known about the error monitoring system in post-traumatic stress disorder (PTSD). PTSD is characterized by impairments in the regulation of fear and other emotional responses, as well as deficits in maintaining cognitive control. Here, combat Veterans with PTSD were compared to control Veterans in two different versions of the flanker task (n=13 or 14 per group). Replicating and extending previous findings, PTSD patients showed an intact ERN in both experiments. In addition, task performance and error compensation behavior were intact. Finally, ERN amplitude showed no relationship with self-reported PTSD, depression, or post-concussive symptoms. These results suggest that error monitoring represents a relative strength in PTSD that can dissociate from cognitive control functions that are impaired, such as response inhibition and sustained attention. A healthy awareness of errors in external actions could be leveraged to improve interoceptive awareness of emotional state. The results could have positive implications for PTSD treatments that rely on self-monitoring abilities, such as neurofeedback and mindfulness training.

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Section: Error-related Negativity and Depressionmentioning

confidence: 49%

Section: Introductionmentioning

confidence: 99%

Intact error monitoring in combat Veterans with post-traumatic stress disorder

Swick

Honzel

Turken

2015

Psychiatry Research: Neuroimaging

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“…For instance, in event-related potentials (ERP) study, it was observed (Holmes and Pizzagalli, 2008) that MDD was associated with a pronounced error negativity effect (ACC signaling) but impaired connectivity between ACC and DLPFC, and abnormal posterior ERP amplitude (Zhu et al, 2010), causing reduced attentional control. Despite of these encouraging findings, neuropsychological studies on inhibition have typically used -7 -the emotional Stroop task, which does not allow distinguishing between active selection of task relevant material and active inhibition of task-irrelevant (emotional) material (Hasher and Zacks, 1988).…”

Section: Introductionmentioning

confidence: 99%

Deficient distracter inhibition and enhanced facilitation for emotional stimuli in depression: An ERP study

Dai

Feng

Koster³

2011

International Journal of Psychophysiology

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The aim of the present study was to investigate distracter inhibition ability and facilitation for emotional faces in depression using a negative affective priming (NAP) task combined with event-related potentials (ERP). Participants were instructed to evaluate the valence of the target, which had been primed or inhibited on a preceding trial. The reaction times and the ERP amplitudes were recorded during the task. In a first behavioral experiment, control participants (NC), participants who were currently remitted (RMD), and participants diagnosed with a current major depressive disorder (MDD), performed a modified the NAP task.The main finding was that compared with NC groups, MDD participants had enhanced positive priming and less inhibition of sad faces. RMD individuals were characterized by general inhibitory impairments for all emotional faces and a facilitation for sad faces compared with NC individuals. In a second experiment combing the modified NAP task with ERP, the MDD participants had a larger P1 and P3 amplitude for sad faces in the positive priming condition compared with the other groups, and smaller P3 amplitude for sad faces in negative priming condition compared with other faces. Interestingly, RMD participants showed a distinct pattern of results compared with NC and MDD participants. They had larger N1 amplitude for happy faces and larger P1 and P3 amplitude for sad faces in the positive priming condition relative to the other conditions, while they had smaller P3 amplitude for both happy and sad faces in the negative priming condition. Across two experiments, it can be concluded that MDD participants have deficient distracter inhibition and excessive facilitation for negative stimuli. The RMD participants showed a mixed pattern of deficient distracter inhibition and excessive facilitation for both positive and negative stimuli, the results were largely consistent with our previous study.This deficiency has a high explanatory value for information-processing bias and the neuropsychological -3 -impairments observed in depression.

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“…Because the hypersensitivity to negative events and the tendency to worry about negative outcomes are hallmarks of several affective personality traits or disorders like anxiety and depression (Maner & Schmidt, 2006;Mineka et al, 2003;Wray & Stone, 2005), one may assume that performance monitoring may vary with these affective personality traits. Consistent with this hypothesis, several studies have reported an effect of anxiety or depression on the ERN (e.g., Aarts & Pourtois;2010;Holmes & Pizzagalli, 2008;Olvet & Hajcak, 2008). By contrast, the evidence supporting a systematic modulation of the FRN (and hence the processing of external evaluative feedback) as a function of negative affect is mixed.…”

mentioning

confidence: 96%

Anxiety disrupts the evaluative component of performance monitoring: An ERP study

Aarts

Pourtois

2012

Neuropsychologia

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Thirty low and 30 high anxious participants performed a speeded Go/noGo task during which they had to rely on evaluative feedback to infer whether their actions were timely (correct) or not. We focused on FRN, an ERP component that is sensitive to the valence of feedback.Depending on the context, neutral faces served either as positive or negative feedback.Whereas the FRN of low anxious individuals did discriminate between neutral faces when used either as positive or negative feedback, the FRN of high anxious individuals did not.However, before the FRN, we also found evidence for a differential perceptual effect at the level of the N170 face-specific component between the two feedback conditions, equally so in low and high anxious individuals. These results suggest that anxiety disrupts selectively the evaluative component of performance monitoring, which presumably allows to ascribe a given value (either positive or negative) to actions.Keywords: Anxiety, ERP, FRN, N170, attribution 3 Performance monitoring and anxiety Anxiety disrupts selectively the evaluative component of performance monitoring: An ERP study Depending on the situation and circumstances, the control of behavior is based on the monitoring of either internal or external signals, or sometimes a combination of both. For example, the adequacy of a given action in response to a familiar stimulus may be determined based on an internal representation allowing to compare the discrepancy between the actual and expected or desired action, with a swift detection of any divergence between the two (Gehring et al., 1993). However, in many situations, performance monitoring cannot be achieved solely based on the processing of internal signals, but the processing of new external feedback information in the environment is required to establish whether the current action is appropriate (e.g., timely, correct) or not. Hence, the processing of feedback information available in the environment often indicates the appropriateness of certain actions and in turn allows to correct or adjust behavior if required, eventually leading to learning and preventing errors from recurring in the future (Holroyd & Coles, 2002;Rabbitt, 1966).Several ERP studies looking at outcome evaluation processes based on external feedback have described an ERP component, the feedback-related negativity (FRN) that is selectively associated with the processing of the valence or motivational significance of the feedback (Gehring & Willoughby, 2002;Holroyd & Coles, 2002;Miltner et al., 1997). The FRN is a negative component peaking at fronto-central electrodes roughly 250-300 ms after presentation of relevant feedback information. Usually, the FRN was found to be larger after negative feedback on task performance, e.g., the presentation of an evaluation signal indicating error commission or monetary loss, compared to positive feedback, e.g., the presentation of an evaluation signal indicating correct performance or monetary reward anxiety, which is usually related to depression (Beck et...

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Spatiotemporal Dynamics of Error Processing Dysfunctions in Major Depressive Disorder

Cited by 251 publications

References 78 publications

Intact error monitoring in combat Veterans with post-traumatic stress disorder

Intact error monitoring in combat Veterans with post-traumatic stress disorder

Deficient distracter inhibition and enhanced facilitation for emotional stimuli in depression: An ERP study

Anxiety disrupts the evaluative component of performance monitoring: An ERP study

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