Spatiotemporal Catalytic Nanozymes Microneedle Patches with Opposite Properties for Wound Management

Abstract

Reactive oxygen species (ROS)‐mediated biological catalysis involves serial programmed enzymatic reactions and plays an important part against infectious diseases; while the spatiotemporal control of catalytic treatment to break the limitations of the disease microenvironment is challenging. Here, a novel spatiotemporal catalytic microneedles patch (CMSP‐MNs) integrated with dual‐effective Cu2MoS4 (CMS) and polydopamine (PDA) nanoparticles (NPs) for breaking microenvironment restrictions to treat wound infections is designed. Since CMS NPs are loaded in the needles, CMSP‐MNs can catalytically generate diverse ROS to cause effective bacterial inactivation during bacterial infection process. Besides, PDA NPs are encapsulated in the backing layer, which facilitate ROS elimination and oxygen production for solving hypoxic problems in wound microenvironment and alleviating the expression of inflammatory factors during the inflammation process. Based on these features, it is demonstrated through cell and animal experiments that these nanozymes‐integrated MNs patches can realize selective regulation of ROS level with bacterial inactivation and inflammatory treatment, resulting in minimized side effects of over‐production ROS and effective anti‐infected treatment. It is believed that the presented MNs can provide a new therapeutic strategy with spatiotemporal adjustable catalytic properties in biomedical areas.

Gold nanoclusters encapsulated microneedle patches with antibacterial and self‐monitoring capacities for wound management

“…Microneedles are needle‐like devices showing advantages in bio‐safety, high mechanical strength, encapsulation possibilities, and many others. [ 12–16 ] Among them, HA microneedles benefit tissue regeneration and drug delivery. [ 17–19 ] In contrast, the GNCs have showed their emerging attracts in biomedical fields, especially the antibiosis studies, due to their multi‐characteristics including bacteriostatic enzyme‐mimic catalytic property, ease of synthesis, size tunability, and good biocompatibility.…”

“…[ 20–25 ] Besides, the unique photoluminescence feature of GNCs enables them to emit bright fluorescence under ultraviolet (UV) light, intriguing GNCs for rapid drug dose monitoring. [ 26–28 ] Although many reports have demonstrated the infected wound healing performances of microneedles or GNC‐based nanomedicine, [ 13,29–32 ] the integration of them remained unexplored. Thus, it is conceived that the encapsulation of antimicrobial GNCs into the microneedles would realize effective drug release and residual dose monitoring in the infected wound healing.…”

pH-Responsive Wound Dressing Based on Biodegradable CuP Nanozymes for Treating Infected and Diabetic Wounds

“…These materials can be principally divided into two categories . One category comprises nanozymes with ROS-generating abilities, exhibiting glucose oxidase (GOD)-like or peroxidase (POD)-like activities, commonly employed in treating infected wounds. , The other includes nanozymes with ROS-scavenging capabilities, displaying catalase (CAT)-like or superoxide dismutase (SOD)-like activities, frequently used to mitigate inflammation and enhance the repair of various acute and chronic wounds . Among these, some nanozymes even showcase pH-adjustable enzymatic activity. , In acidic environments, these nanozymes exhibit a predisposition toward peroxidase (POD) or oxidase (OXD) enzymatic activities, whereas under alkaline conditions, they tend to manifest superoxide dismutase (SOD) or catalase (CAT) enzymatic activities. , Numerous studies have suggested that this distinctive property equips these nanozymes with the capacity to exert therapeutic effects in various contexts.…”