2016
DOI: 10.1371/journal.pone.0156499
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Spatio-Temporal History of HIV-1 CRF35_AD in Afghanistan and Iran

Abstract: HIV-1 Circulating Recombinant Form 35_AD (CRF35_AD) has an important position in the epidemiological profile of Afghanistan and Iran. Despite the presence of this clade in Afghanistan and Iran for over a decade, our understanding of its origin and dissemination patterns is limited. In this study, we performed a Bayesian phylogeographic analysis to reconstruct the spatio-temporal dispersion pattern of this clade using eligible CRF35_AD gag and pol sequences available in the Los Alamos HIV database (432 sequence… Show more

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Cited by 12 publications
(7 citation statements)
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“…The picture of the HIV-1 epidemic in the Middle East is more obscure with the exception of Iran, as the majority of the Middle East countries lacked sequences in LADB (Bahrain, Iraq, Jordan, Occupied Palestinian Territories, Oman, Qatar, Syria, and United Arab Emirates). In Iran, CRF35_AD dominated the HIV-1 epidemic, particularly among IDUs as has been shown previously ( Eybpoosh et al, 2016 ). The overall complex genetic diversity of HIV-1 in the MENA has been previously reported by Rolland and Modjarrad, and our results are in line with their conclusions ( Rolland and Modjarrad, 2015 ).…”
Section: Discussionsupporting
confidence: 76%
“…The picture of the HIV-1 epidemic in the Middle East is more obscure with the exception of Iran, as the majority of the Middle East countries lacked sequences in LADB (Bahrain, Iraq, Jordan, Occupied Palestinian Territories, Oman, Qatar, Syria, and United Arab Emirates). In Iran, CRF35_AD dominated the HIV-1 epidemic, particularly among IDUs as has been shown previously ( Eybpoosh et al, 2016 ). The overall complex genetic diversity of HIV-1 in the MENA has been previously reported by Rolland and Modjarrad, and our results are in line with their conclusions ( Rolland and Modjarrad, 2015 ).…”
Section: Discussionsupporting
confidence: 76%
“…Although the presence of WNV infection remains unknown in countries without data in the EMRO region (n = 14), it can be implied that the virus may probably circulate within these countries as well. Existing evidence suggests cross-country dispersion of a number of viruses such as human immunodeficiency virus (HIV) [91] and hepatitis B virus (HBV) [92]. These observations can imply the hypothesis in which WNV also have dispersed across countries in the region, affecting localities (countries) adjacent to infected areas.…”
Section: Discussionmentioning
confidence: 99%
“…Overlooking the problem of substitution saturation is common in the field. While saturation occurs more rapidly in fast-evolving pathogens [2], few studies have well addressed this issue in their phylogenetic analyses [810]. …”
mentioning
confidence: 99%