Spatially resolved monitoring of powder mixing processes via multiple NIR-probes

Scheibelhofer, Otto; Balak, Nikolaus; Koller, Daniel; Khinast, Johannes G.

doi:10.1016/j.powtec.2013.03.035

Cited by 34 publications

(28 citation statements)

References 31 publications

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“…Modeling has been applied to determine LOD trajectories, particle size distributions (PSD) as function of time and process conditions and particle densities as function of processing conditions [23][24][25][27][28][29][30].…”

Section: Fluid Bed Granulation Modelingmentioning

confidence: 99%

“…1-D PBMs have been most commonly used to model crystallization [1,35,55],until recently, when some 2-D models have also been developed to describe the crystallization processes [16,27,34,54]. Certain 2-D models also employ the volume and surface area in order to account for the shape of particles [47].…”

Section: Crystallizationmentioning

confidence: 99%

“…Much of this work has been focused on determining if the shear cell measurements are applicable for specific situations [22]. In addition, changes in various aspects of the procedure (ones not dictated by the standards) have been studied [27]. Lastly, some studies have been conducted that compare the measurements of a particular shear cell parameter between different types of shear testers [28].…”

Section: Shear Cellmentioning

confidence: 99%

“…Findings were consistent with experimental observations. Yu and Saxen [27] also investigated these flow regimes using DEM simulations.…”

Section: Hoppers and Feedersmentioning

confidence: 99%

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Process Simulation and Data Modeling in Solid Oral Drug Development and Manufacture

Ierapetritou¹,

Ramachandran²

2016

Methods in Pharmacology and Toxicology

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Section: Fluid Bed Granulation Modelingmentioning

confidence: 99%

Section: Crystallizationmentioning

confidence: 99%

Section: Shear Cellmentioning

confidence: 99%

“…Findings were consistent with experimental observations. Yu and Saxen [27] also investigated these flow regimes using DEM simulations.…”

Section: Hoppers and Feedersmentioning

confidence: 99%

See 2 more Smart Citations

Process Simulation and Data Modeling in Solid Oral Drug Development and Manufacture

Ierapetritou¹,

Ramachandran²

2016

Methods in Pharmacology and Toxicology

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“…A single probe may fail or may become useless due to several reasons; very common is the occurrence of fouling. Thus, a multipoint system provides a better monitoring quality and control of the coating process, for example, with regard to coating homogeneity and endpoint control of a process (21)(22)(23). Different positions inside the coating vessel were evaluated regarding their susceptibility for fouling and their reliability.…”

Section: Introductionmentioning

confidence: 99%

Monitoring of a Hot Melt Coating Process via a Novel Multipoint Near-Infrared Spectrometer

et al. 2016

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Abstract. The aim of the present work was to develop a PAT strategy for the supervision of hot melt coating processes. Optical fibers were placed at various positions in the process chamber of a fluid bed device. Experiments were performed to determine the most suitable position for in-line process monitoring, taking into account such requirements as a good signal to noise ratio, the mitigation of dead zones, the ability to monitor the product over the entire process, and reproducibility. The experimental evidence suggested that the position at medium fluid bed height, looking towards the center, i.e., normal to particle movement, proved to be the most reliable position. In this study, the advantages of multipoint monitoring are shown, and an in-line-implementation was created. This enabled the real-time supervision of the process, including the fast detection of inhomogeneities and disturbances in the process chamber, and the compensation of sensor malfunction. In addition, a model for estimating the particle size distribution via NIR was successfully created. This ensures that the quality of the product and the endpoint of the coating process can be determined correctly.

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Experimental Study of Flow and Heat Transfer in Granular Media

Shahidin,

Siraj

2024

Chem Eng & Technol

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In this paper, granular flow is studied using particle image velocimetry (PIV) in two different geometries, that is, rectangular box and cylindrical bladed mixer. Effects of parameters like blade rake angle, bed height, moisture content, and the number of blades were studied. The shear rate and velocity magnitude of granular bed were calculated using PIV. The presence of moisture in the granular bed added additional cohesive forces and reduced shear rate between different layers of particles. Shear rate and shear forces were maximal at the tip of the blade. Temperature variations in the granular bed were measured experimentally and results were compared for static and mixing beds.

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Spatially resolved monitoring of powder mixing processes via multiple NIR-probes

Cited by 34 publications

References 31 publications

Process Simulation and Data Modeling in Solid Oral Drug Development and Manufacture

Process Simulation and Data Modeling in Solid Oral Drug Development and Manufacture

Monitoring of a Hot Melt Coating Process via a Novel Multipoint Near-Infrared Spectrometer

Experimental Study of Flow and Heat Transfer in Granular Media

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