Journal of Cell Biology volume 214, issue 2, P125-127 2016 DOI: 10.1083/jcb.201606123 View full text
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Giusi Caldieri, Sara Sigismund

Abstract: G protein–coupled receptor signaling starts at the plasma membrane and continues at endosomal stations. In this issue, Inda et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201512075) show that different forms of adenylyl cyclase are activated at the plasma membrane versus endosomes, providing a rationale for the spatial encoding of cAMP signaling.