Spatial representation of odorant valence in an insect brain

Ahsan, Jawaid; Knaden, Markus; Strutz, Antonia; Sachse, Silke; Hansson, Bill S.

doi:10.1016/j.mod.2017.04.310

Cited by 1 publication

(2 citation statements)

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“…The odor panel was chosen to ensure diversity in functional groups, behavioral valence, activation patterns and concentrations (Badel et al, 2016;Knaden et al, 2012;Strutz et al, 2014) . For example, benzaldehyde (Bzald) was reported to be repulsive (Ahsan et al, 2017;Strutz et al, 2014) and activate ventral glomeruli strongly compared with other stimuli (Badel et al, 2016) , whereas ethyl acetate (EA) is regarded as an attractive cue that generates strong input to dorso-medial glomeruli (Ahsan et al, 2017). The light-sheet images acquired were segmented using an unsupervised non-negative matrix factorization method (Pnevmatikakis et al, 2016) (see Methods for details).…”

Section: Light-sheeting Imaging Of Odor Evoked Neural Activitymentioning

confidence: 99%

“…The ePNs and iPNs can influence each other's activity through chemical synapses (Shimizu and Stopfer, 2017). While the importance of the ePN and iPN activity for odor recognition is well established (Ahsan et al, 2017;Parnas et al, 2013;Strutz et al, 2014) , how the ePN and iPN activities are spatially organized and patterned over time to facilitate odor recognition remains poorly understood.…”

Section: Introductionmentioning

confidence: 99%

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Spatial and Temporal Organization of Odor-evoked Responses in a Fly Olfactory Circuit: Inputs, Outputs and Idiosyncrasies

Rong

Zhang²,

Greer³

et al. 2020

Preprint

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How is sensory information routed through different types of neurons within a circuit, and do equivalent circuits in different individuals follow similar organizational principles? We examined this issue in the fruit fly olfactory system. Odor-evoked signals from sensory neurons (ORNs) triggered neural responses that were patterned over space and time in cholinergic ePNs and GABAergic iPNs within the antennal lobe. The dendritic-axonal (I/O) response mapping was complex and diverse, and axonal organization was region-specific (mushroom body vs. lateral horn). In the lateral horn, feed-forward excitatory and inhibitory axonal projections matched 'odor tuning' in a stereotyped, dorsal-lateral locus, but mismatched in most other locations. In the temporal dimension, ORN, ePN and iPN odor-evoked responses had similar encoding features, such as information refinement over time and divergent ON and OFF responses. Notably, analogous spatial and temporal coding principles were observed in all flies, and the latter emerged from idiosyncratic neural processing approaches.

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